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Accelerated atrial pacing reduces left-heart filling pressure: a combined clinical-computational study.
Eur Heart J
December 2024
Department of Biomedical Engineering, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Universiteitssingel 40, 6229 ER Maastricht, The Netherlands.
Background And Aims: Accelerated atrial pacing offers potential benefits for patients with heart failure with preserved ejection fraction (HFpEF) and atrial fibrillation (AF), compared with standard lower-rate pacing. The study investigates the relationship between atrial pacing rate and left-heart filling pressure.
Methods: Seventy-five consecutive patients undergoing catheter ablation for AF underwent assessment of mean left atrial pressure (mLAP) and atrioventricular (AV) conduction delay (PR interval) in sinus rhythm and accelerated atrial pacing with 10 bpm increments up to Wenckebach block.
Diagnosis and management of hypertrophic cardiomyopathy: European vs. American guidelines.
Heart Fail Rev
November 2024
Hypertrophic Cardiomyopathy Center, Lahey Hospital, Burlington, MA, USA.
Hypertrophic cardiomyopathy (HCM) is the most common genetic heart disease, affecting 1:200 to 1:500 individuals worldwide. Guidelines on the diagnosis and management of HCM have been recently published by the European Society of Cardiology (ESC) and American societies. The ESC guidelines cover a broad range of cardiomyopathies, including HCM, with 119 recommendations, whereas the American guidelines focus exclusively on HCM with 141 specific recommendations.
View Article and Find Full Text PDFTreatment of malignant primary cardiac tumors requires attention to cardiovascular complications: a single-center, retrospective study.
Jpn J Clin Oncol
October 2024
Department of Oncology and Social Medicine, Kyushu University Graduate School of Medical Sciences, Higashi-ku, Fukuoka, Japan.
Article Synopsis
- - The study analyzed records of 47 patients with primary cardiac tumors from Kyushu University Hospital, finding that 13 (28%) were diagnosed with malignant tumors, including various sarcomas and lymphomas, highlighting the rarity of such cases.
- - Cardiovascular complications were prevalent, with 77% of patients experiencing issues like heart dysfunction, arrhythmias, and right heart failure, often linked to the aggressive multimodal treatment involving surgery, chemotherapy, and radiotherapy.
- - Two cases exemplified severe complications: one patient faced significant heart failure post-treatment, while another developed a heart block due to tumor placement, indicating the need for careful management to improve patient outcomes.
Study on ultrasound diagnosis and pathological anatomy of fetal complex congenital heart disease in the first trimester.
J Clin Ultrasound
January 2025
Obstetrics Department, Guangxi Maternity & Child Healthcare Hospital, Nanning, China.
Purpose: To assess the feasibility of using the stereo-microscope to identify the pathological anatomy of the congenital heart diseases in the first trimester.
Methods: Fifteen fetuses of 8-12 weeks aborted due to prevent miscarriage failure and 42 fetuses of 11-14 weeks with congenital heart diseases were included in the study, we dissected their hearts through a stereo-microscope, then compared with the prenatal ultrasonographic diagnosis.
Results: Using stereomicroscopy, the positive view of the heart and the great arteries, the long axis view of the aortic arch, the inflow tract view of the bottom heart, the semilunar valve view of the bottom heart, and the transverse section of the ventricle were showed contented and obtained satisfactory images, but the structure of atrioventricular valve and venous system had a lower rate of display.
Modeling the atrioventricular conduction axis using human pluripotent stem cell-derived cardiac assembloids.
Cell Stem Cell
November 2024
Department of Medical Biology, Amsterdam Cardiovascular Sciences, Amsterdam University Medical Centers, University of Amsterdam, Meibergdreef 9, Amsterdam 1105 AZ, the Netherlands. Electronic address:
The atrioventricular (AV) conduction axis provides electrical continuity between the atrial and ventricular chambers. The "nodal" cardiomyocytes populating this region (AV canal in the embryo, AV node from fetal stages onward) propagate impulses slowly, ensuring sequential contraction of the chambers. Dysfunction of AV nodal tissue causes severe disturbances in rhythm and contraction, and human models that capture its salient features are limited.
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