SMARCB1 (INI1)-deficient carcinoma of the sinonasal tract is a rare and distinct entity characterized by the loss of INI1 immunostain expression. These tumors are morphologically diverse, with isolated cases of yolk sac differentiation reported. We report the first case of SMARCB1-deficient sinonasal carcinoma that demonstrated co-loss of SMARCA4 immunostain, and reduced SMARCA2 and ARID1A staining, with the entire tumor showing histological and immunohistochemical evidence of yolk sac differentiation. The clinical, histological, immunohistochemical and molecular features were discussed and compared against SMARCB1-deficient sinonasal carcinomas with yolk sac differentiation and SMARCA4-deficeint sinonasal carcinomas reported in the literature. With a highly aggressive clinical course leading to mortality two months after presentation, the behavior of this tumor appears to be more comparable to that of SMARCA4-deficient sinonasal carcinomas. A comprehensive immunopanel including SMARCB1, SMARCA4, SMARCA2 and ARID1A may be advisable for assessment and prognostication of SWI/SNF-deficient tumors.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9424504 | PMC |
| http://dx.doi.org/10.1007/s12105-022-01423-y | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Effects of Formula Product Injection on Hatching Parameters, Small Intestinal Development and Ileum Histology in Breeder Chicken Eggs.
Vet Med Sci
January 2025
Department of Agricultural Biotechnology, Faculty of Agriculture, University of Kırşehir Ahi Evran, Kırşehir, Türkiye.
Background And Objective: This study aimed to determine the effects of in ovo formula product injection on hatching parameters, chick quality, small intestinal development and ileum histology of breeder hen eggs.
Methods: A total of 400 fertilised eggs were obtained from the Atak-S parent flock at 42 weeks of age for the experiment. The experiment was designed in two groups: a control group (C), in which no injection was performed, and the other group in which a solution containing formula products at concentrations of 1.
Effects of the Dietary Blue-Green Algae (Spirulina platensis) Supplementation and Egg Storage Period on Egg Quality Traits, Blastoderm Characteristics and Hatching Results of Mast Geese (Anser anser).
J Anim Physiol Anim Nutr (Berl)
January 2025
Department of Animal Science, Faculty of Agriculture, Tekirdağ Namık Kemal University, Tekirdağ, Turkey.
This study aimed to determine the effects of the dietary Spirulina platensis supplementation and egg storage period on egg quality traits, blastoderm characteristics and hatching results of Mast geese. For this purpose, the control group was fed the standard enterprise diet, while the experimental group received the same diet supplemented with 0.5% S.
View Article and Find Full Text PDFGerm cell tumors in children.
Virchows Arch
January 2025
Department of Pathology and Laboratory Medicine, University of Miami Miller School of Medicine, Miami, FL, USA.
Pediatric germ cell tumors represent a rare but biologically diverse group of neoplasms arising from pluripotent primordial germ cells. The 2022 edition of the WHO Classification of Pediatric Tumors introduced the first organ independent classification of germ cell tumors, reflecting advances in molecular biology, histopathology, and clinical practice. This review highlights the key changes, including the refined distinctions between the different subtypes.
View Article and Find Full Text PDFDivergent destinies: insights into the molecular mechanisms underlying EPI and PE fate determination.
Life Sci Alliance
March 2025
https://ror.org/05f950310 Department of Development and Regeneration, Stem Cell Institute, KU Leuven, Leuven, Belgium
Mammalian pre-implantation development is entirely devoted to the specification of extra-embryonic lineages, which are fundamental for embryo morphogenesis and support. The second fate decision is taken just before implantation, as defined by the epiblast (EPI) and the primitive endoderm (PE) specification. Later, EPI forms the embryo proper and PE contributes to the formation of the yolk sac.
View Article and Find Full Text PDFExtracranial and nonvaginal extragonadal malignant germ cell tumors: 12 cases at a Chinese institution over the last 38 years.
Arch Gynecol Obstet
January 2025
Department of Obstetrics and Gynecology, National Clinical Research Center for Obstetric & Gynecologic Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Purpose: To provide a comprehensive understanding and propose a strategy for the management of extragonadal malignant germ cell tumors (EMGCTs) arising from extracranial and nonvaginal sites.
Methods: We retrospectively reviewed the cases of 12 patients with EMGCTs arising from extracranial and nonvaginal sites treated in our center over the past 38 years. Data on clinicopathological characteristics, treatment modalities, and follow-up information were analyzed.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!