Patients with obsessive-compulsive disorder (OCD) exhibit abnormality in their subjective perception of internal sensation, a process known as interoceptive sensibility (IS), as well as altered functioning of the insula, a key neural structure for interoception. We investigated the multivariate structure of IS in 77 OCD patients and 53 controls and examined associations of IS with resting-state functional connectivity (FC) of the insula within the OCD group. For each group, principal component analysis was performed on 8 subscales of the Multidimensional Assessment of Interoceptive Awareness assessing putatively "adaptive" and "maladaptive" aspects of IS. Associations between IS components and insula FC in the OCD group were evaluated using seed regions placed in each of 3 subdivisions of the insula (posterior, anterior dorsal, and anterior ventral). Behaviorally, controls showed a 2-component solution broadly categorized into "adaptive" and "maladaptive" IS, while OCD patients exhibited a 3-component solution. The general tendency to notice or be aware of sensation loaded onto an "adaptive" IS component in controls but loaded onto both "adaptive" and "maladaptive" IS components in OCD. Within OCD, insula FC was differentially associated with distinct aspects of IS, identifying network connections that could serve as future targets for the modulation of IS in OCD.
Background: Chronic arterial hypertension restructures the vascular architecture of the brain, leading to a series of pathological responses that culminate in cerebral small-vessel disease. Pericytes respond dynamically to vascular challenges; however, how they manifest under the continuous strain of hypertension has not been elucidated.
Methods And Results: In this study, we characterized pericyte behavior alongside hypertensive states in the spontaneously hypertensive stroke-prone rat model, focusing on their phenotypic and metabolic transformation.
This study tested predictions from Processing Mode Theory, Self-Distancing Theory, and the Construal Matching Hypothesis by manipulating processing mode (abstract vs. concrete), self-perspective (self-distanced vs. self-immersed), and the construal level of emotion (high-level vs.
Prior research has examined self-leadership as a proactive self-regulatory approach for the management of stress and anxiety in college students. However, little is known about the possible negative effects of self-regulatory approaches such as self-leadership. Using the transactional model of stress and coping and the interaction model of stress, anxiety, and coping as theoretical frameworks, this study investigates a parallel multiple mediation model of the relationship between self-leadership and state anxiety as mediated by adaptive coping behaviours and maladaptive coping behaviours in a sample of 143 undergraduate students.
The drive to seek information through exploratory behavior is widespread in both humans and other animals. This can be adaptive in reducing uncertainty about the best course of action within novel or changing environments. However, exploratory behaviors can also become maladaptive if subjective uncertainty levels remain too high or too low, as may happen in states of elevated anxiety.
Background: Restrictive eating behaviors, widespread in humans and animals, are often conceptualized as maladaptive, but may serve adaptive purposes under specific circumstances.
Aim: To investigate the adaptive potential of restrictive eating behaviors.
Methods: Computational models explored the relationship between food availability, basal metabolic rate, and restrictive eating behaviors.
