The effect of low flow anesthesia with sevoflurane on oxidative status: A prospective, randomized study.

Saudi Med J

From the Department of Anesthesiology and Reanimation (Kaşıkara, Dumanlı Özcan), Ankara City Hospital, from the Department of Medical Biochemistry (Biçer), School of Medicine; from the Department of General Surgery (Yalçın); from the Department of Anesthesiology and Reanimation (Aksoy, But); Ankara Yıldırım Beyazıt University, and from the Department of Anesthesiology and Reanimation (Altın), Hacettepe University, Ankara, Turkey.

Published: March 2022

AI Article Synopsis

  • The study aimed to evaluate how different flow rates of sevoflurane anesthesia (low, mid, and high) affect oxidative stress in surgical patients by measuring thiol and disulfide levels.
  • A total of 99 patients were randomly divided into three groups, each receiving varying fresh gas flow rates during anesthesia, with blood samples taken at different times to assess oxidative markers.
  • Results showed that mid-flow and low-flow anesthesia reduced disulfide levels compared to high-flow anesthesia, suggesting that low-flow anesthesia helps prevent oxidative damage in patients.

Article Abstract

Objectives: To assess the impact of low-flow, mid-flow, and high-flow sevoflurane anesthesia on the oxidative state by measuring thiol/disulfide levels in patients undergoing surgery.

Methods: The study included 99 patients randomly assigned to 3 groups. In the low-flow anesthesia group, the fresh gas flow was diminished to 1 L.min for anesthesia maintenance after 6 L.min was administered for the first 10 minutes. In the mid-flow anesthesia group, fresh gas flow was applied as 2 L.min. In the high-flow anesthesia group, the fresh gas flow was administered as 4 L.min throughout the operation. Blood samples were obtained before induction, at the 60th minute after induction, and at 2 hours postoperatively. Native thiol, total thiol, disulfide analyzed and disulfide/native thiol percentage, disulfide/total thiol percentage, and native thiol/total thiol percentage were calculated.

Results: Disulfide values in mid-flow and low-flow anesthesia were significantly lower at the 60th minute after induction compared to the high-flow anesthesia group. In the group evaluations, intraoperative native thiol levels in the high-flow group were found to be substantialy lower than preoperative values.

Conclusion: It was sighted that low-flow anesthesia with sevoflurane prohibited oxidative damage. It was concluded that low flow anesthesia can be utilized safely in this respect.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9280541PMC
http://dx.doi.org/10.15537/smj.2022.43.3.20210876DOI Listing

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