AI Article Synopsis
- - The exact causes of colorectal cancer (CRC) remain unclear, but genetic and environmental factors, along with the bacterium Fusobacterium nucleatum, may play a role in its development and potential early diagnosis.
- - A review of 57 studies found a significant association between F. nucleatum and CRC, showing its presence in cancerous tissue samples at higher rates compared to healthy tissue and colorectal adenomas.
- - The findings suggest that F. nucleatum is more frequently linked with CRC, but additional research is necessary to confirm this relationship and understand its implications.
Article Abstract
Introduction: The etiological factors of colorectal cancer (CRC) are not precisely known, although genetic and environmental factors have been implicated. A possible association with Fusobacterium nucleatum may provide opportunities for an early diagnosis.
Objective: To review studies that address the association between F. nucleatum and CRC.
Methods: The MEDLINE PubMed database was searched using the terms «colorectal cancer» and "Fusobacterium nucleatum", retrieving publications published up to January 1 2020. Stata software was used for a meta-analysis.
Results: The systematic review included 57 articles. Meta-analysis results indicated a more frequent presence of F. nucleatum in CRC tumour tissue samples in comparison to control samples of healthy tissue, with an odds ratio of 4.558 (95% CI: 3.312-6.272), and in comparison, to control samples of colorectal adenomas, with an odds ratio of 3.244 (95 % CI: 2.359-4.462).
Conclusion: There is a more frequent resence of F. nucleatum in the CRC. However, further studies are needed to verify this relationship.
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| http://dx.doi.org/10.1016/j.eimce.2022.02.007 | DOI Listing |
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