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HIV1-Nef perturbs the integrity of blood testis barrier in rat model.
Tissue Barriers
May 2024
Endocrinology Division, CSIR-Central Drug Research Institute, Lucknow, India.
The blood-testis barrier is a specialized feature within the mammalian testis, located in close proximity to the basement membrane of seminiferous tubules. This barrier serves to divide the seminiferous epithelium into distinct basal and adluminal (apical) compartments. The selectivity of the BTB to foreign particles makes it a safe haven for the virus, and the high affinity of HIV for testis might lead to the vertical transmission of the virus.
View Article and Find Full Text PDFIncreased hexosamine biosynthetic pathway flux alters cell-cell adhesion in INS-1E cells and murine islets.
Endocrine
September 2023
DiSTeBA, Centro Ecotekne, Strada Monteroni, University of Salento, 73100, Lecce, Italy.
Purpose: In type 2 Diabetes, β-cell failure is caused by loss of cell mass, mostly by apoptosis, but also by simple dysfunction (dedifferentiation, decline of glucose-stimulated insulin secretion). Apoptosis and dysfunction are caused, at least in part, by glucotoxicity, in which increased flux of glucose in the hexosamine biosynthetic pathway plays a role. In this study, we sought to clarify whether increased hexosamine biosynthetic pathway flux affects another important aspect of β-cell physiology, that is β-cell-β-cell homotypic interactions.
View Article and Find Full Text PDFApoptosis signal-regulating kinase-1 regulates thrombin-induced endothelial permeability.
Vascul Pharmacol
August 2022
Cardeza Center for Hemostasis, Thrombosis, and Vascular Biology, Cardeza, Foundation for Hematologic Research, Department of Medicine, Division of Hematology, Sydney Kimmel Medical College, Thomas Jefferson University, Philadelphia, USA. Electronic address:
Thrombin-induced endothelial permeability is associated with various pathological conditions. Apoptosis signal-regulating kinase-1 (ASK1), one of the upstream MAP3K, has been reported to be an important regulator of endothelial stress and apoptosis. Despite this, its role in endothelial permeability is unknown.
View Article and Find Full Text PDFPhosphorylation of Focal Adhesion Kinase at Y925: Role in Glia-Dependent and Independent Migration through Regulating Cofilin and N-Cadherin.
Mol Neurobiol
June 2022
Institute for Structural Neurobiology, Center for Molecular Neurobiology, University Medical Center Hamburg-Eppendorf, 20251, Hamburg, Germany.
The adult neocortex is a six-layered structure, consisting of nearly continuous layers of neurons that are generated in a temporally strictly coordinated order. During development, cortical neurons originating from the ventricular zone migrate toward the Reelin-containing marginal zone in an inside-out arrangement. Focal adhesion kinase (FAK), one tyrosine kinase localizing to focal adhesions, has been shown to be phosphorylated at tyrosine 925 (Y925) by Src, an important downstream molecule of Reelin signaling.
View Article and Find Full Text PDF[E-cadherin dislocation in invasive mammary lobular carcinoma].
Ann Pathol
July 2022
Service de pathologie morphologique, département de biologie et pathologie médicales, Gustave-Roussy Cancer Campus, Villejuif, France.
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