A smart probe for simultaneous imaging of the lipid/water microenvironment in atherosclerosis and fatty liver.

Chem Commun (Camb)

Department of Respiratory and Critical Care Medicine, Targeted Tracer Research and Development Laboratory, Precision Medicine Key Laboratory of Sichuan Province & Precision Medicine Center, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China.

Published: March 2022

A smart lipid droplet specific fluorescent probe (LDs-DM) with dual-emission in water (706 nm) and oil (535 nm) under single-excitation was prepared for revealing the ultra-structure of the aqueous and lipidic microenvironment in living cells, fatty liver tissues and atherosclerotic plaques without fluorescence emission crosstalk. This work is expected to provide inspiration for designing a novel probe with color switching ability.

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Source
http://dx.doi.org/10.1039/d2cc00795aDOI Listing

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