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Cytologic diagnosis of fumarate hydratase-deficient renal cell carcinoma: A single-institutional experience.
Cancer Cytopathol
February 2025
Department of Pathology, Stanford University School of Medicine, Stanford, California, USA.
Background: Fumarate hydratase-deficient renal cell carcinoma (FHRCC) is an aggressive carcinoma that typically presents as advanced-stage disease. Prompt recognition of FHRCC is critical for appropriate clinical care and genetic counseling for patients and family members. However, diagnosing FHRCC from cytology specimens is challenging, with limited characterization and no reports describing prospectively identified cases.
View Article and Find Full Text PDFCase report: Triple-negative breast cancer with low tumour-infiltrating lymphocytes infiltration and good prognosis: a case of Tall Cell Carcinoma with Reversed Polarity and review of the literature.
Front Oncol
November 2024
Department of Breast, The Third Affiliated Hospital of Beijing University of Chinese Medicine, Beijing, China.
Article Synopsis
- Triple-negative breast cancer (TNBC) presents significant treatment challenges due to high recurrence rates and absence of known therapeutic targets; however, tumor-infiltrating lymphocytes (TILs) have been associated with better survival rates in TNBC cases.
- A unique case of TNBC, named Tall Cell Carcinoma with Reversed Polarity (TCCRP), was studied, revealing low TILs infiltration but a good prognosis in a 54-year-old woman despite being triple-negative for common markers.
- The findings suggest TCCRP may have distinct biological behaviors with low TILs, possibly due to the presence of Cancer-Associated Fibroblasts (CAF) that could hinder anti-tumor immunity, warrant
[Application of 9-gene panel in assisting fine needle aspiration cytology to diagnose thyroid cancer].
Zhonghua Zhong Liu Za Zhi
November 2024
Department of Pathology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing100021, China.
Article Synopsis
- The study investigates the effectiveness of a 9-gene panel for diagnosing thyroid nodules that have indeterminate cytological results, compared to traditional BRAF V600E single-gene detection.
- Researchers analyzed 579 thyroid nodule samples from patients, using next-generation sequencing to identify mutations in nine specific genes associated with cancer.
- The results showed that 47.5% of tested nodules had mutations, with a majority of identified malignant cases linked to the BRAF gene, demonstrating the panel's potential as a diagnostic tool alongside standard cytology methods.
The value and sensitivity of contrast-enhanced ultrasonography combined with fine-needle aspiration biopsy in the diagnosis of thyroid nodules.
Sci Rep
November 2024
Department of Ultrasonic, Shanxi Provincial People's Hospital, 29 shuangtaisi street, yingze district, Taiyuan, Shanxi, 030001, China.
Article Synopsis
- This study assessed the effectiveness of combining contrast-enhanced ultrasonography (CEUS) with fine-needle aspiration biopsy (FNAB) for diagnosing thyroid nodules in 120 patients.
- Results showed that CEUS-guided FNAB had significantly higher sensitivity, specificity, and overall accuracy compared to using CEUS alone, particularly in identifying various types of thyroid cancer.
- The findings suggest that this combined approach not only helps differentiate between benign and malignant nodules but also aids in determining the type and stage of thyroid cancer, enhancing diagnostic value significantly.
Prediction of lateral lymph node metastasis with short diameter less than 8 mm in papillary thyroid carcinoma based on radiomics.
Cancer Imaging
November 2024
Department of Ultrasonography, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China.
Objective: The aim of this study was to establish an ensemble learning model based on clinicopathological parameter and ultrasound radomics for assessing the risk of lateral cervical lymph node with short diameter less than 8 mm (small lymph nodes were used instead) metastasis in patients with papillary thyroid cancer (PTC), thereby guiding the selection of surgical methods.
Methods: This retrospective analysis was conducted on 454 patients diagnosed with papillary thyroid carcinoma who underwent total thyroidectomy and lateral neck lymph node dissection or lymph node intraoperative frozen section biopsy at the First Hospital of China Medical University between January 2015 and April 2022. In a ratio of 8:2, 362(80%) patients were assigned to the training set and 92(20%) patients were assigned to the test set.
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