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One of the areas with the potential to be explored in quantum computing (QC) is machine learning (ML), giving rise to quantum machine learning (QML). In an era when there is so much data, ML may benefit from either speed, complexity or smaller amounts of storage. In this work, we explore a quantum approach to a machine learning problem. Based on the work of Mari et al., we train a set of hybrid classical-quantum neural networks using transfer learning (TL). Our task was to solve the problem of classifying full-image mammograms into malignant and benign, provided by BCDR. Throughout the course of our work, heatmaps were used to highlight the parts of the mammograms that were being targeted by the networks while evaluating different performance metrics. Our work shows that this method may hold benefits regarding the generalization of complex data; however, further tests are needed. We also show that, depending on the task, some architectures perform better than others. Nonetheless, our results were superior to those reported in the state-of-the-art (accuracy of 84% against 76.9%, respectively). In addition, experiments were conducted in a real quantum device, and results were compared with the classical and simulator.
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http://dx.doi.org/10.1007/s42484-022-00062-4 | DOI Listing |
Chembiochem
March 2025
Sirius university of Science and Technology, Research Center for Translational Medicine, Olympic Ave., 1, 354340, Sochi, RUSSIAN FEDERATION.
Fluorescent protein-based biosensors are indispensable molecular tools in cell biology and biomedical research, providing non-invasive dynamic measurements of metabolite concentrations and other cellular signals. Traditional methods for developing these biosensors rely on rational design, but directed evolution methods offer a more efficient alternative. This review discusses recent advancements in the development of biosensors using directed evolution, including methods for optimizing domain fusions, sequence optimization, and new screening and selection systems.
View Article and Find Full Text PDFCNS Neurosci Ther
March 2025
Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan, P.R. China.
Background: Gliomas represent the most aggressive malignancies of the central nervous system, with posttranslational modifications (PTMs) emerging as critical regulators of oncogenic processes through dynamic protein functional modulation. Despite their established role in tumor biology, the systematic characterization of PTM-mediated molecular mechanisms driving glioma progression remains unexplored. This study aims to uncover the molecular mechanisms of glioma, with a focus on the role of PTMs.
View Article and Find Full Text PDFHPB (Oxford)
March 2025
Department of Surgery, The Ohio State University Wexner Medical Center and James Comprehensive Cancer Center, Columbus, OH, USA. Electronic address:
Background: Despite technical advancements, minimally invasive liver surgery (MILS) for hepatocellular carcinoma (HCC) remains challenging. Nonetheless, effective tools to assess MILS complexity are still lacking. Machine learning (ML) models could improve the accuracy of such tools.
View Article and Find Full Text PDFHPB (Oxford)
March 2025
Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
Background: Laparoscopic repeat liver resection (LRLR) is still a challenging technique and requires a careful selection of indications. However, the current difficulty scoring system is not suitable for selecting indications. The purpose of this study is to develop the indication model for LRLR using machine learning and to identify factors associated with open conversion (OC).
View Article and Find Full Text PDFJ Immunother Cancer
March 2025
Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang, China
Background: Accurate prediction of pathologic complete response (pCR) following neoadjuvant immunotherapy combined with chemotherapy (nICT) is crucial for tailoring patient care in esophageal squamous cell carcinoma (ESCC). This study aimed to develop and validate a deep learning model using a novel voxel-level radiomics approach to predict pCR based on preoperative CT images.
Methods: In this multicenter, retrospective study, 741 patients with ESCC who underwent nICT followed by radical esophagectomy were enrolled from three institutions.
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