Objective: Disrupted brain functional asymmetry has been reported in major depressive disorder (MDD). The comorbidity may be a crucial factor to this functional asymmetry. It is quite common that gastrointestinal (GI) symptoms are comorbid with MDD, but limited evidence focuses on the effect of GI comorbidity on the neuropathology of MDD from a functional lateralization perspective.
Methods: Resting-state functional magnetic resonance imaging was obtained in 28 healthy controls (HCs), 35 MDD patients with GI symptoms (GI-MDD patients), and 17 patients with MDD without GI symptoms (nGI-MDD patients). The parameter of asymmetry (PAS) was used to analyze the imaging data and evaluate the changes of functional asymmetry.
Results: The GI-MDD patients showed increased PAS scores in the left inferior frontal gyrus (IFG) and superior medial prefrontal cortex (MPFC) and decreased PAS scores in the right postcentral gyrus in comparison with nGI-MDD patients. The PAS scores of the left IFG and left superior MPFC were correlated with the severity of GI problems and could be applied to distinguish GI-MDD patients from nGI-MDD patients with an accuracy, a sensitivity, and a specificity of 92.31, 100, and 76.47%, respectively. Furthermore, GI-MDD and nGI-MDD patients both displayed increased PAS scores in the PCC/precuneus.
Conclusions: This study revealed the influence of concomitant GI symptoms on functional asymmetry in MDD patients. Increased PAS scores of the left IFG and superior MPFC might represent an unbalanced regulation of brain over GI function and had the potential to be regarded as distinctive features related to functional GI symptoms in MDD.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8891942 | PMC |
| http://dx.doi.org/10.3389/fnins.2021.797598 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
CNN-Based Cross-Modality Fusion for Enhanced Breast Cancer Detection Using Mammography and Ultrasound.
Tomography
December 2024
Department of Medical Imaging and Radiological Science, I-Shou University, Kaohsiung City 824005, Taiwan.
Breast cancer is a leading cause of mortality among women in Taiwan and globally. Non-invasive imaging methods, such as mammography and ultrasound, are critical for early detection, yet standalone modalities have limitations in regard to their diagnostic accuracy. This study aims to enhance breast cancer detection through a cross-modality fusion approach combining mammography and ultrasound imaging, using advanced convolutional neural network (CNN) architectures.
View Article and Find Full Text PDFPAS or Not PAS? The Sonographic Assessment of Placenta Accreta Spectrum Disorders and the Clinical Validation of a New Diagnostic and Prognostic Scoring System.
J Imaging
December 2024
Obstetrics and Gynaecology Unit, Department of Interdisciplinary Medicine (DIM), University of Bari, 70124 Bari, Italy.
This study aimed to evaluate our center's experience in diagnosing and managing placenta accreta spectrum (PAS) in a high-risk population, focusing on prenatal ultrasound features associated with PAS severity and maternal outcomes. We conducted a retrospective analysis of 102 high-risk patients with confirmed placenta previa who delivered at our center between 2018 and 2023. Patients underwent transabdominal and transvaginal ultrasound scans, assessing typical sonographic features.
View Article and Find Full Text PDFToward workforce integration: enhancements in adaptive behaviors and social communication skills among autistic young adults following vocational training course.
Front Psychol
December 2024
Bruckner Center for Autism Research, Department of Communication Disorders, Ariel University, Ariel, Israel.
Background: Cognitively able autistic adults demonstrate low rates of employment due to social and vocational challenges. The current study aimed to examine changes in various areas among autistic young adults who participated in the 'Roim Rachok' ('Looking Ahead' in Hebrew) Training Course (RRTC). The course prepares young autistic adults for integration into military service as vocational soldiers.
View Article and Find Full Text PDFIntegrative multi-omic analysis reveals potential biomarkers in the cervicovaginal fluid of patients with placenta accrete spectrum.
BMC Pregnancy Childbirth
December 2024
Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.
Objective: This study aimed to detect the proteins and metabolites in the cervicovaginal fluid to observe their relationship with the occurrence of placenta accreta spectrum and the potential biomarkers with predictive value.
Methods: Cervicovaginal fluid samples were collected before delivery from 6 participants of PAS and 6 controls subjects with similar gestational ages. The severity of PAS was evaluated by ultrasound and MRI scoring system and confirmed by the intraoperative findings or pathological examination.
Clinical Relevance of Computational Pathology Analysis of Interplay Between Kidney Microvasculature and Interstitial Microenvironment.
Clin J Am Soc Nephrol
December 2024
Department of Biomedical engineering, Emory University, Atlanta, GA, USA.
Background: Interstitial fibrosis and tubular atrophy (IFTA), and density and shape of peritubular capillaries (PTCs), are independently prognostic of disease progression. This study aimed to identify novel digital biomarkers of disease progression and assess the clinical relevance of the interplay between a variety of PTC characteristics and their microenvironment in glomerular diseases.
Methods: A total of 344 NEPTUNE/CureGN participants were included: 112 minimal change disease, 134 focal segmental glomerulosclerosis, 61 membranous nephropathy, and 37 IgA nephropathy.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!