Early diagnosis of COVID-19, the new coronavirus disease, is considered important for the treatment and control of this disease. The diagnosis of COVID-19 is based on two basic approaches of laboratory and chest radiography, and there has been a significant increase in studies performed in recent months by using chest computed tomography (CT) scans and artificial intelligence techniques. Classification of patient CT scans results in a serious loss of radiology professionals' valuable time. Considering the rapid increase in COVID-19 infections, in order to automate the analysis of CT scans and minimize this loss of time, in this paper a new method is proposed using BO (BO)-based MobilNetv2, ResNet-50 models, SVM and kNN machine learning algorithms. In this method, an accuracy of 99.37% was achieved with an average precision of 99.38%, 99.36% recall and 99.37% F-score on datasets containing COVID and non-COVID classes. When we examine the performance results of the proposed method, it is predicted that it can be used as a decision support mechanism with high classification success for the diagnosis of COVID-19 with CT scans.
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http://dx.doi.org/10.1007/s00521-022-07052-4 | DOI Listing |
Virol J
January 2025
Medi-X Pingshan, Southern University of Science and Technology, Shenzhen, Guangdong, 518118, China.
Background: SHEN26 (ATV014) is an oral RNA-dependent RNA polymerase (RdRp) inhibitor with potential anti-SARS-CoV-2 activity. Safety, tolerability, and pharmacokinetic characteristics were verified in a Phase I study. This phase II study aimed to verify the efficacy and safety of SHEN26 in COVID-19 patients.
View Article and Find Full Text PDFMalar J
January 2025
Department of Parasitology-Mycology and Tropical Medicine, Université Des Sciences de La Santé de Libreville, BP 4009, Libreville, Gabon.
Background: The negative impact of COVID-19 pandemic on healthcare service utilization has been reported in several countries. In Gabon, data on the preparedness for future pandemic are lacking. The aim of the present study was to assess the trends of hospital attendance, malaria and self-medication prevalences as well as ITN use before and during Covid-19 first epidemic waves in a paediatric wards of a sentinel site for malaria surveillance, in Libreville, Gabon.
View Article and Find Full Text PDFAnal Chim Acta
February 2025
Department of Physical and Analytical Chemistry & Institute of Biotechnology of Asturias, University of Oviedo, c/Julián Clavería 8, 33006, Oviedo, Spain. Electronic address:
The COVID-19 outbreak was an important turning point in the development of a new generation of biosensing technologies. The synergistic combination of an immunochromatographic test (lateral flow immunoassays, LFIA) and signal transducers provides enhanced sensitivity and the ability to quantify in the rapid tests. This is possible due to the variety of nanoparticles that can be used as reporter labels.
View Article and Find Full Text PDFLancet Neurol
February 2025
Department of Neurology, International University of Health and Welfare, Narita, Japan.
Background: Evidence from preclinical studies suggests that IL-6 signalling has the potential to modulate immunopathogenic mechanisms upstream of autoantibody effector mechanisms in patients with generalised myasthenia gravis. We aimed to assess the safety and efficacy of satralizumab, a humanised monoclonal antibody targeting the IL-6 receptor, in patients with generalised myasthenia gravis.
Methods: LUMINESCE was a randomised, double-blind, placebo-controlled, multicentre, phase 3 study at 105 sites, including hospitals and clinics, globally.
Infect Dis (Lond)
January 2025
Department of Medicine, V.N. Karazin Kharkiv National University, Kharkiv, Ukraine.
Human Metapneumovirus (HMPV) is a re-emerging respiratory pathogen causing significant morbidity and mortality, particularly among young children, the elderly, and immunocompromised individuals. First identified in 2001, HMPV has since been recognised as a leading cause of acute respiratory tract infections (ARTIs) worldwide. Its transmission occurs through droplets, direct contact, and surface contamination, with crowded spaces and healthcare facilities serving as key environmental amplifiers.
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