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Intravesical administration of highly concentrated hyaluronic acid and chondroitin sulfate as add-on therapy for chemical cystitis induced by Bacillus Calmette-Guérin (BCG) immunotherapy.
Int Urol Nephrol
January 2025
Department of Medical, Surgical and Neurological Science, University of Siena, Siena, Italy.
Purpose: Intravesical (i) immunotherapy with Bacillus Calmette-Guérin (BCG) is the recommended treatment for patients with intermediate- and high-risk non-muscle-invasive bladder cancer (NMIBC) after complete tumor resection. Discontinuation or suspension of this therapy is often due to local side effects. Aim of the study was to evaluate the efficacy and safety of sequential intravesical instillations of combined hyaluronic acid (HA) and chondroitin sulfate (CS) in reducing local BCG toxicity and urinary symptoms.
View Article and Find Full Text PDFManagement of Lower Urinary Tract Symptoms during the Treatment for Non-Muscle Invasive Bladder Cancer.
Curr Urol Rep
January 2025
Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Article Synopsis
- The review discusses current treatment methods and strategies for managing lower urinary tract symptoms (LUTS) linked to treatments like transurethral resection and intravesical therapy.
- Recent findings highlight that while there's limited research, some oral agents and new therapies show promise in alleviating LUTS associated with intravesical treatments, such as phenazopyridine and beta-3 agonists.
- The review emphasizes the need for more research to validate these treatments and to develop effective strategies for managing LUTS in patients undergoing various intravesical therapy regimens.
Intravesical Therapies for Recurrent Urinary Tract Infections: A Systematic Review.
Cureus
October 2024
Department of Urology, Gloucestershire Hospitals NHS Foundation Trust, Cheltenham, GBR.
Recurrent urinary tract infections (rUTIs) present a significant clinical challenge, particularly due to the associated overuse of antibiotics and the rise in antimicrobial resistance. This systematic review evaluates the current literature on the use of intravesical therapies as an alternative treatment for rUTIs. Two established primary therapies are reviewed: glycosaminoglycan (GAG) instillations and intravesical antibiotic instillations.
View Article and Find Full Text PDFMedical Management of Refractory Haematuria in Palliative Patients.
J Pain Symptom Manage
November 2024
Gloucestershire Hospitals NHS Foundation Trust, Cheltenham, UK.
The management of haematuria, in patients with a palliative diagnosis, refractory to standard measures presents a significant challenge for multidisciplinary teams. Our experiences with two cases led us to review the literature and highlighted the limited evidence base. We describe the cases here and propose options for medical approaches to management.
View Article and Find Full Text PDFIntravesical Instillation of Hyaluronic Acid With Epidermal Growth Factor for Restoring Urothelial Denudation and Alleviating Oxidative Stress in Lipopolysaccharide-Induced Interstitial Cystitis of Rats.
Int Neurourol J
June 2024
Department of Obstetrics and Gynecology, School of Medicine, Taipei Medical University, Taipei, Taiwan.
Purpose: To investigate the efficacy of an intravesical instillation of hyaluronic acid (HA) combined with epidermal growth factor (EGF) for the treatment of interstitial cystitis (IC) using a lipopolysaccharide (LPS)-induced IC animal model.
Methods: A total of 24 female Sprague-Dawley rats were randomized to 4 groups: sham control, IC, HA, and treatment (HA/ EGF) groups. A polyethylene-50 tube was placed inside the bladder of each animal.
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