AI Article Synopsis
- Growing interest in targeted cancer therapies using alpha-emitting radionuclides has led to the need for precise measurements of their activity to ensure proper dosing and patient-specific calculations.
- National metrology institutes globally are working on developing standards for measuring the activity of clinically relevant alpha emitters, which is essential for consistent results.
- The review outlines the methodologies, generation of new decay data, and the implications for both preclinical and clinical use of radionuclide calibrators and γ-ray spectrometry.
Article Abstract
Interest in targeted cancer therapy with alpha-emitting radionuclides is growing. To evaluate emerging radiotherapeutic agents requires precise activity measurements for consistent dose-response relationships and patient-specific dosimetry. National metrology institutes around the world have reported on the development and comparison of activity standards for medically important alpha emitters. This review describes the relevant methods and models underpinning these standards, the generation of new nuclear decay data, and the impacts on preclinical and clinical activity assays using radionuclide calibrators and γ-ray spectrometry.
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| http://dx.doi.org/10.1016/j.apradiso.2022.110161 | DOI Listing |
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