AI Article Synopsis
- The study examined how diet-induced obesity affects maternal-fetal outcomes in pregnant females, revealing that obesity leads to lower placental efficiency and lower birth weights in pups.
- Maternal obesity disrupts the relationship between maternal and fetal health, potentially due to hormonal signaling issues and increased inflammation in the mother's metabolism.
- Changes in placental structure and growth factor expression, like reduced EGFR levels, were linked to poor fetal outcomes, while maintaining maternal glucose levels and higher PGF expression offered some protection against these issues.
Article Abstract
The aim of this study was to investigate certain parameters regarding the maternal-fetal outcomes in a diet-induced obesity model. Obese, glucose-intolerant females who were exposed to a high-fat diet prior to pregnancy had lower placental efficiency and lower birth weight pups compared to the controls. Simple linear regression analyses showed that maternal obesity disrupts the proportionality between maternal and fetal outcomes during pregnancy. Maternal obesity is correlated with fetal outcomes, perhaps because of problems with hormonal signaling and exacerbation of inflammation in the maternal metabolic environment. The maternal obese phenotype altered the thickness of the placental layer, the transport of fatty acids, and the expression of growth factors. For example, lower expression of epidermal growth factor receptor (EGFR) mRNA in the obesity-prone group may have contributed to the rupture of the placental layers, leading to adverse fetal outcomes. Furthermore, maintenance of maternal glucose homeostasis and overexpression of placental growth factor (PGF) in the obesity-resistant group likely protected the placenta and fetuses from morphological and functional damage.
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| http://dx.doi.org/10.1016/j.jnutbio.2022.108977 | DOI Listing |
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