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http://dx.doi.org/10.1016/j.ajog.2022.02.031 | DOI Listing |
Int J Pharm
December 2024
State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau 999078, China; Faculty of Health Sciences, University of Macau, Macau 999078, China. Electronic address:
Messenger RNA (mRNA) encapsulated in lipid nanoparticles (LNPs) represents a cutting-edge delivery technology that played a pivotal role during the COVID-19 pandemic and in advancing vaccine development. However, molecular structure of mRNA-LNPs at real size remains poorly understood, with conflicting results from various experimental studies. In this study, we aim to explore the assembly process and structural characteristics of mRNA-LNPs at realistic sizes using coarse-grained molecular dynamic simulations.
View Article and Find Full Text PDFCell Chem Biol
December 2024
Department of Molecular Biology and Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address:
The surge of antimicrobial resistance threatens efficacy of current antibiotics, particularly against Pseudomonas aeruginosa, a highly resistant gram-negative pathogen. The asymmetric outer membrane (OM) of P. aeruginosa combined with its array of efflux pumps provide a barrier to xenobiotic accumulation, thus making antibiotic discovery challenging.
View Article and Find Full Text PDFJ Environ Manage
December 2024
College of Geography and Remote Sensing Sciences, Xinjiang Key Laboratory of Oasis Ecology, Xingjiang University, Urumqi, 830017, China. Electronic address:
The accumulation of plastic waste from various sources into marine and inland water is considered a global problem due to its serious impacts on aquatic ecosystems and human health. In the past decade, remote sensing has played an important role in monitoring of plastic pollution in marine and inland water sources and has achieved a series of research results in this field. In this study, a comprehensive review was conducted on the development, opportunities, and challenges of datasets and methods in Marine and Inland Water Plastics Remote Sensing (MIWPRS) monitoring over the past decade, based on the Web of Science (WOS) core database.
View Article and Find Full Text PDFBioresour Technol
December 2024
Laboratory of Reactions and Process Engineering, Université de Lorraine, CNRS, 1, rue Grandville, BP 20451, Nancy Cedex 54001, France.
High-solid anaerobic digestion (HSAD) can be used to treat organic waste. However, the operating stability is limited by the hydraulic conditions; therefore, regulation is essential. The flow field contains a large amount of information that cannot be directly regulated.
View Article and Find Full Text PDFEnviron Res
December 2024
Energy School, Xi'an University of Science and Technology, Xi'an, 710054, China. Electronic address:
Fluidity influences the use of backfill materials in the mining industry. A new backfill material-modified magnesium slag-based backfill materials (MFPB)-is made from solid waste from coal and metallurgy. We focus on the compatibility of polycarboxylate water reducing agent (SP) with MFPB and its effect on MFPB performance.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!