Background: A new, green and environmentally friendly protocol has been developed for the synthesis of tetrahydrodipyrazolopyridine derivatives. The structures of these products were determined in terms of melting point, FTIR, NMR and Mass spectroscopy.
Results: The tetrahydrodipyrazolopyridine derivatives were synthesized in water through a catalyst-free pseudo-six-component reaction of hydrazine hydrate, ethyl acetoacetate, ammonium acetate and aldehyde at room temperature.
Conclusions: This novel procedure has some advantages such as aqueous media, high yield and simple work-up.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8897970 | PMC |
| http://dx.doi.org/10.1186/s13065-022-00802-4 | DOI Listing |
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