Plants in the genus have been widely used as traditional medicines in Asian countries. These plants contain bioactive compounds with neuroprotective properties or activities that increase neural stem cells (NSCs) and neurons. However, bioactive components in that promote the differentiation of NSCs into astrocytes have not yet been reported. Here, the effects of extracts on the differentiation of embryonic stem-cell-derived NSCs were evaluated. The extract of the wild turmeric, , strongly promoted the differentiation of NSCs into astrocytes. Bioassay-guided isolation yielded coronarins C () and D (), as well as ()-labda-8(17),12-diene-15,16-dial () as the bioactive compounds. Coronarin D () markedly promoted the differentiation of NSCs into astrocytes up to approximately 4 times (3.64 ± 0.48) and increased the expression level of GFAP at the mRNA and protein level, while compounds and exhibited only weak effects, suggesting that the 15-hydroxy-Δ-γ-lactone moiety is important for bioactivity. Moreover, compound increased the number of pSTAT3-positive cells, suggesting that compound promoted astrocytic differentiation through JAK/STAT signaling pathway.
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| http://dx.doi.org/10.1021/acs.jafc.2c00020 | DOI Listing |
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