A GLUTs/GSH cascade targeting-responsive bioprobe, GluCC, was rationally designed and synthesized for the first time the coordination of copper ions with a glucose-modified coumarin derivative ligand (GluC). GluCC can specifically detect circulating tumor cells (CTCs) in lung metastatic mice models by targeting the Warburg effect and responding to overexpressed glutathione in the tumor microenvironment. This bioprobe with a simple detection procedure has significant advantages for CTC detection.
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A GLUTs/GSH cascade targeting-responsive bioprobe for the detection of circulating tumor cells.
Chem Commun (Camb)
March 2022
Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling, Shaanxi 712100, P. R. China.
A GLUTs/GSH cascade targeting-responsive bioprobe, GluCC, was rationally designed and synthesized for the first time the coordination of copper ions with a glucose-modified coumarin derivative ligand (GluC). GluCC can specifically detect circulating tumor cells (CTCs) in lung metastatic mice models by targeting the Warburg effect and responding to overexpressed glutathione in the tumor microenvironment. This bioprobe with a simple detection procedure has significant advantages for CTC detection.
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