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The Role of as a Candidate Prognosis Biomarker in Esophageal Squamous Cell Carcinoma. | LitMetric

Esophageal squamous cell carcinoma (ESCC) is one of the most prevalent malignancies with unfavorable clinical outcomes and limited therapeutic methods. As a key enzyme in RNA metabolism, debranching RNA Lariats 1 (DBR1) is involved in intron turnover and biogenesis of noncoding RNA. Although cancer cells often show disorder of nucleic acid metabolism, it is unclear whether has any effect on the carcinogenesis and progression of ESCC. Here we detected DBR1 expression in 112 ESCC samples by immunohistochemistry and analyzed its correlation with clinical parameters and survival. DBR1 is mainly located in the nucleus of ESCC tissue. And DBR1 was associated with several malignant clinical features in patients, including tumor location ( = 9.687,  = .021), pathologic T stage ( = 5.771,  = .016), lymph node metastasis ( = 8.215,  = .004) and N classification ( = 10.066,  = .018). Moreover, Kaplan-Meier analysis showed that ESCC patients harboring lower DBR1 expression had a worse prognosis in comparison with those with higher DBR1 expression ( = .005). Univariate and multivariate Cox proportional hazards regression analyses indicated that decreased DBR1 might act as an independent predictor of poor prognosis for ESCC patients. Abnormal RNA metabolism might play a critical role in promoting the progression of ESCC, and may be a promising potential biomarker for predicting the prognosis of ESCC patients.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8902023PMC
http://dx.doi.org/10.1177/15330338221083105DOI Listing

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