Round-window stimulating transducer is a new solution to treat mixed hearing loss. To uncover the factors affecting the round-window stimulation's performance, we investigated the influence of four main design parameters of round-window stimulating type electromagnetic transducer. Firstly, we constructed a human ear nonlinear lumped parameter model and confirmed its validity by comparing the stapes responses predicted by the model with the experimental data. Following this, an electromagnetic transducer's mechanical model, which simulates the floating mass transducer, was built and coupled to the human ear model; thereby, we established a nonlinear lumped parameter model of implanted human ear under round-window stimulation and verified its reliability. Finally, based on this model, the influences of the four main design parameters, i.e., the excitation voltage, the electromechanical coupling coefficient, the support stiffness, and the preload force, were analyzed. The results show that the change of excitation voltage does not alter the system's natural frequency. Chaotic motion occurs when the electromechanical coupling coefficient is small. Meanwhile, the stapes displacement appears to increase firstly and then decrease with the increase of the electromechanical coupling coefficient. The increase of the support stiffness enlarges the resonance frequency of the stapes displacement and reduces the stapes displacement near the resonance frequency, deteriorating the transducer's hearing compensation at low frequency. The preload force can improve the transducer's hearing compensation performance in mid-high frequency region.
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http://dx.doi.org/10.3934/mbe.2022113 | DOI Listing |
Int J Mol Sci
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Ocular Genomics Institute, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA.
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View Article and Find Full Text PDFAnimals (Basel)
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Department of Clinical Studies, Ontario Veterinary College, University of Guelph, Guelph, ON N1G2W1, Canada.
Veterinarians are essential in antimicrobial stewardship. Companion animal (CA) practitioners have recently received more attention. There are few relevant studies on CA antimicrobial prescribing practices in South Asia.
View Article and Find Full Text PDFSci Rep
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Atmosphere and Ocean Research Institute, The University of Tokyo, Kashiwa, 277-8564, Chiba, Japan.
Migration routes and the depth patterns of anguillid eel larvae migrating long distances from spawning grounds in the ocean remain poorly understood. We used otolith stable isotope analysis to study the oceanic migrations of anguillid eels by reconstructing experienced water temperature histories of larvae. The otolith stable oxygen isotopes (δO) of recruited Anguilla japonica glass eels were analyzed to assess the relationship with the experienced water temperature of the early larval stage in laboratory experiments.
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Laboratory for Neuroengineering, Department of Health Science and Technology, Institute for Robotics and Intelligent Systems, ETH Zürich, Zürich, Switzerland; NeuroEngineering Laboratory, Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria. Electronic address:
Neuroprosthetics research has entered a stage in which animal models and proof-of-concept studies are translated into clinical applications, often combining implants with artificial intelligence techniques. This new phase raises the question of how clinical trials should be designed to scientifically and ethically address the unique features of neural prostheses. Neural prostheses are complex cyberbiological devices able to acquire and process data; hence, their assessment is not reducible to only third-party safety and efficacy evaluations as in pharmacological research.
View Article and Find Full Text PDFStem Cell Reports
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Department of Otolaryngology-Head and Neck Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA; Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202, USA. Electronic address:
The mechanical properties in the inner ear microenvironment play a key role in its patterning during embryonic development. To recapitulate inner ear development in vitro, three-dimensional tissue engineering strategies including the application of representative tissue models and scaffolds are of increasing interest. Human inner ear organoids are a promising model to recapitulate developmental processes; however, the current protocol requires Matrigel that contains ill-defined extracellular matrix components.
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