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Affinity-Enriched Plasma Proteomics for Biomarker Discovery in Abdominal Aortic Aneurysms.
Proteomes
December 2024
Center for Clinical Proteomics, Odense University Hospital, 5000 Odense, Denmark.
Abdominal aortic aneurysm (AAA) is a life-threatening condition characterized by the weakening and dilation of the abdominal aorta. Few diagnostic biomarkers have been proposed for this condition. We performed mass spectrometry-based proteomics analysis of affinity-enriched plasma from 45 patients with AAA and 45 matched controls to identify changes to the plasma proteome and potential diagnostic biomarkers.
View Article and Find Full Text PDFTraumatic Dissection of the Ascending Aorta Complicated by Multiple Injuries Following a Traffic Accident.
Cureus
November 2024
Department of Cardiovascular Surgery, Tokyo Metropolitan Bokutoh Hospital, Tokyo, JPN.
Trauma to the ascending aorta may progress to a cardiac tamponade, which is often life-threatening. Here, we report on a case of traumatic dissection of the ascending aorta, complicated by multiple injuries. A 24-hour follow-up period was provided to evaluate the traumatic bleeding, and a large tear that extended over three-quarters of the circumference of the aortic intima was identified.
View Article and Find Full Text PDFMechanism and management of aorto-oesophageal fistulation after thoracic endovascular aortic repair.
Ann Vasc Surg
December 2024
Department of Cardiac and Vascular Surgery, University Medical Centre Mainz, Johannes Gutenberg University, Mainz, Germany.
An aorto-oesophageal fistula (AOF) is a pathological communication between the thoracic aorta and the oesophagus. It can induce life-threatening hematemesis, which is unique among the other types of gastrointestinal haemorrhage in that the vomiting is bright red and represents an arterial bleed. Nevertheless, it is notable that over 70% of cases are associated with thoracic aortic aneurysms, particularly as a postoperative complication following open surgery, and arguably more so following endovascular repair.
View Article and Find Full Text PDFCasual detection of an abdominal aortic aneurysm thanks to a trainee-made ultrasound with two subsequent "domino" diagnoses: case report and insights on the role of ultrasound courses.
J Ultrasound
December 2024
Geriatrics Unit, Garibaldi-Nesima Hospital, Catania, Italy.
Early detection of abdominal aortic aneurysm (AAA) is crucial as untreated lesions can be life-threatening. We describe the case of a fortuitous ultrasound (US) detection of AAA by a trainee which allowed two subsequent "domino" diagnoses. A 69 y.
View Article and Find Full Text PDF[DNA Methylation Profiling in Aneurysm and Comorbid Atherosclerosis of the Ascending Aorta].
Mol Biol (Mosk)
December 2024
Institute of Medical Genetics, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, 634050 Russia.
Atherosclerosis and aneurysm of the aorta are relatively common pathological conditions that remain asymptomatic for a long period of time and have life-threatening and disabling complications. DNA methylation profiling in several regions (a dilated area, a nondilated area, and an atherosclerotic plaque) of the ascending aorta was carried out in patients with aortic aneurysm. DNA methylation was analyzed by reduced representation bisulfite sequencing (RRBS).
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