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Efficient chemical synthesis of mirror-image DNA polymerase Dpo4 assisted by one-pot multi-segment condensation.
Org Biomol Chem
March 2025
Hefei National Research Center for Interdisciplinary Sciences at the Microscale, University of Science and Technology of China, 230027 Hefei, China.
The mirror-image DNA polymerase Dpo4 is a valuable enzymatic tool in biomedical research; however, its chemical synthesis has been hindered by low efficiency. Here, we describe an efficient chemical synthesis of D-Dpo4 using a one-pot multi-segment condensation strategy, which was achieved using Fmoc-masked peptide thioester. By minimizing the need for isolating and handling intermediates through one-pot three- and four-segment ligations, we were able to obtain D-Dpo4 with higher efficiency, achieving an improved overall yield of 9.
View Article and Find Full Text PDFSodium aescinate induces hepatotoxicity through apoptosis and ferroptosis by inhibiting the Nrf2/CTH pathway.
J Ethnopharmacol
March 2025
School of Medicine, Yichun University, 576 XueFu Road, Yuanzhou District, Yichun, 336000, PR China. Electronic address:
Ethnopharmacological Relevance: The seed of Aesculus wilsonii Rehd., also known as Suoluozi in China, is a traditional Chinese herb included in the Pharmacopoeia of China (2020). Sodium aescinate (SA) is derived from the Aesculus wilsonii Rehd.
View Article and Find Full Text PDFEnhancing Liquid-Vapor Phase-Change Heat Transfer with Micro/Nano-Structured Surfaces.
ACS Nano
March 2025
School of Energy and Power Engineering, Huazhong University of Science and Technology, Wuhan 430074, China.
Liquid-vapor phase-change heat transfer plays an important role in many industrial systems, ranging from power generation and air conditioning to water desalination, food processing, and thermal management of electronics and data centers. Recent advances in micro/nanofabrication have enabled desirable manipulation of multiscale dynamics governing droplet/bubble motion and capillary liquid flows for highly efficient phase-change heat transfer. However, there lacks a comprehensive review on the design and fabrication of micro/nanostructured surfaces with controlled morphology and wettability, to enhance the diverse phase-change heat transfer processes.
View Article and Find Full Text PDFA facile approach for generating ordered oxygen vacancies in metal oxides.
Nat Mater
March 2025
School of Materials Science and Engineering, State Key Laboratory of New Ceramic Materials, Tsinghua University, Beijing, China.
Oxygen vacancies in oxide materials, although demonstrated to be beneficial for many applications, are hard to be generated and manipulated as desired, particularly for bulk materials with a large size and limited surface area. Here, by simply coupling the thermal activation with a simultaneously applied electric field, we efficiently generate ordered oxygen vacancies within bulk crystals of ternary SrAlO, binary TiO and other common oxide materials, which give rise to superior functionalities. We expect that this approach offers a general and practical way for the vacancy engineering of oxide materials and holds great promise for their applications.
View Article and Find Full Text PDFEyring theory for plasticity in amorphous polymers violates Curie's principle.
Soft Matter
March 2025
Univ. Lyon, CNRS, INSA Lyon, Université Claude Bernard Lyon 1, MATEIS, UMR5510, 69100 Villeurbanne, France.
In 1936, Eyring introduced a model for plastic flow which still forms the bedrock of practically all studies on plasticity of glassy polymers. Though the concept of activated process he introduced is fundamentally relevant, we argue here that under no circumstances can the Eyring model be correct as it violates Curie's principle, which is a basic physical requirement of statistical mechanics. An alternative model was proposed by [Long , , 2018, , 105601] to describe the acceleration of the dynamics by an applied stress, in which the elastic energy stored at the length scale of dynamical heterogeneities ≈ 3 - 5 nm reduces the free energy barriers for relaxation.
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