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Prevalence of cardiometabolic outcomes in women who underwent salpingo-oophorectomy to prevent hereditary breast and ovarian cancer: a meta-analysis.
Fam Cancer
November 2024
Ophir Loyola Hospital, Belém, Pará, 66063-240, Brazil.
Article Synopsis
- Risk reduction salpingo-oophorectomy (RRSO) is a surgery often performed on women with hereditary breast and ovarian cancer (HBOC) syndrome caused by BRCA1 and BRCA2 mutations, which leads to surgical menopause and potential health risks.
- A meta-analysis of six studies involving 1,320 patients examined the rates of cardiovascular and metabolic conditions post-surgery, including myocardial infarction, hypertension, hypercholesterolemia, and type 2 diabetes.
- The results showed that while there were increased prevalence rates for conditions like hypertension (28%) and hypercholesterolemia (27.2%), the overall cardiovascular risk did not significantly increase for women undergoing RRSO.
Efficacy and Safety of Evolocumab and Alirocumab as PCSK9 Inhibitors in Pediatric Patients with Familial Hypercholesterolemia: A Systematic Review and Meta-Analysis.
Medicina (Kaunas)
October 2024
Department of Pediatrics, West China Second Hospital, Sichuan University, Chengdu 610041, China.
Article Synopsis
- PCSK9 inhibitors, evolocumab and alirocumab, show promise in treating familial hypercholesterolemia (FH) in pediatric patients through a systematic review and meta-analysis.
- The analysis included 14 articles and found that these drugs significantly reduced low-density lipoprotein cholesterol (LDL-C) and other lipid markers, particularly in patients with heterozygous FH.
- Overall, the medications were well tolerated in children, highlighting their potential for safe use in managing lipid levels compared to prior studies in adults.
Sleep and nighttime behavior disorders in older adults: associations with hypercholesterolemia and hypertriglyceridemia at baseline, and a predictive analysis of incident cases at 12 months follow-up.
Lipids Health Dis
September 2024
Biologie Intégrative et Physiologie - Parcours Neurosciences Cellulaires et Integrées, Faculté des Sciences et Ingénierie, Campus Pierre Et Marie Curie, Sorbonne Université, Paris, France.
Introduction: Sleep disorders, particularly insomnia and obstructive sleep apnea, are associated with dyslipidemia in the general population. The study's aim was to explore the association between pathological Cholesterol and Triglyceride levels, and sleep and nighttime behavior disorders (SNBD) in older adults, whether they might predict SNBD onset, and to emphasize the role of body mass index (BMI) in this association.
Methods: Alzheimer's Disease Neuroimaging Initiative (ADNI) population with complete Cholesterol, Triglyceride, SNBD, and neurocognitive data were included.
Fermented pomace improves the nutritive value of eggs, enhances ovarian function, and reshapes microbiota abundance in aged laying hens.
Front Microbiol
June 2024
Department of Food Science and Engineering, College of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen, China.
Introduction: There is a decline in the quality and nutritive value of eggs in aged laying hens. Fruit pomaces with high nutritional and functional values have gained interest in poultry production to improve the performance.
Methods: The performance, egg nutritive value, lipid metabolism, ovarian health, and cecal microbiota abundance were evaluated in aged laying hens (320 laying hens, 345-day-old) fed on a basal diet (control), and a basal diet inclusion of 0.
Cardiovascular outcomes in patients with homozygous familial hypercholesterolaemia on lipoprotein apheresis initiated during childhood: long-term follow-up of an international cohort from two registries.
Lancet Child Adolesc Health
July 2024
Department of Paediatrics, Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands.
Background: Homozygous familial hypercholesterolaemia (HoFH) is a rare genetic disease characterised by extremely high plasma LDL cholesterol from birth, causing atherosclerotic cardiovascular disease at a young age. Lipoprotein apheresis in combination with lipid-lowering drugs effectively reduce LDL cholesterol, but long-term health outcomes of such treatment are unknown. We aimed to investigate the long-term cardiovascular outcomes associated with lipoprotein apheresis initiated in childhood or adolescence.
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