AI Article Synopsis
- - Ferroptosis is a distinct form of regulated cell death that differs from other types like apoptosis and necroptosis, offering new insights into cell death mechanisms.
- - Targeting ferroptosis holds promise as a novel approach in cancer therapy, particularly for aggressive tumors that are resistant to traditional chemotherapy treatments.
- - The text discusses how manipulating abnormal metabolic processes in cancer cells can trigger ferroptosis, with an emphasis on research related to blood cancers.
Article Abstract
Ferroptosis, a new type of regulated cell death, displays characteristics that transparently differ from apoptosis, autophagy and necroptosis. There is growing appreciation that targeting ferroptosis is potentially a novel strategy in anti-tumor therapy, especially for invasive malignancies demonstrating resistance to chemotherapy. Almost all types of cancer cells depend on abnormal metabolic activities to participate in vicious progression, giving the possibility to interfere with underlying metabolic preferences and compromise malignant cells by inducing ferroptosis. In this perspective, we give an overview of potential interactions between ferroptosis and abnormal tumor metabolism, with special focus on systematic researches in hematological malignancies.
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| http://dx.doi.org/10.1016/j.biopha.2022.112747 | DOI Listing |
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