Transcatheter medical micro-devices through circulatory system show great potential for therapy but lack strategies to stably anchor them at the desired site in vascularized tissues to take actions. Here a shape memory functionalized biodegradable magnetic micro-anchor (SMA) is developed to achieve magnetic guided endovascular localization through precisely controlled shape transformation. The SMA comprises anisotropic polylactide-based microparticle embedded with superparamagnetic FeO nanoparticles, exhibiting thermally activated tunable shape recovery modes at a body-friendly temperature range to accomplished an efficient endovascular anchoring effect in both decellularized liver organ and rabbit ear embolization models. The SMA can be anchored at the target micro-vessel, exhibiting a controlled radial expansion of the vessel wall yielding with estimated stresses of 7-26 kPa in contact stress and 38-218 kPa in von Mises stress. The SMA is a promising platform to incorporate diagnostic or therapeutic agents for precision deployment and in-situ action.
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| http://dx.doi.org/10.1016/j.biomaterials.2022.121426 | DOI Listing |
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