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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8893326 | PMC |
| http://dx.doi.org/10.1371/journal.pntd.0010226 | DOI Listing |
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Dissolved oxygen is crucial for metabolism, growth, and other complex physiological and pathological processes; however, standard physiological models (such as organ-on-chip systems) often use ambient oxygen levels, which do not reflect the lower levels that are typically found . Additionally, the local generation of reactive oxygen species (ROS; a key factor in physiological systems) is often overlooked in biology-mimicking models. Here, we present a microfluidic system that integrates electrochemical dissolved oxygen sensors with lab-on-a-chip technology to monitor the physiological oxygen concentrations and generate hydrogen peroxide (HO; a specific ROS).
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