Purpose Of The Review: Preparative fasting orders arose out of a purported need to enhance imaging studies, reduce interference of food with intended medical/surgical interventions, and protect the patient from vomiting and aspiration pneumonia. This review discusses the frequency, appropriateness, and efficacy of fasting orders in meeting those needs and whether their use should be modified in the future.
Recent Findings: Nil per os (NPO) orders are overused, as they are often inappropriate, typically excessive, and routinely create barriers which may increase risk for patients. Fasting orders are used more often for medical procedures than for surgical operations or imaging studies. One fourth of NPO orders are inappropriate, and the intended procedure or study is canceled 20% of the time usually for a change in plans or scheduling error and rarely because of patient eating. Nausea/vomiting associated with contrast media or imaging studies is rare, self-limited, and not linked to preparatory fluid or food ingestion. Prolonged fasting reduces patient cooperation and satisfaction, and may contribute to a higher rate of complications. Each institution should review and revise preparative fasting orders. Drinking of fluids should be allowed without restriction. Truncated periods of solid food restriction may be required due to technical reasons related to specific imaging studies, and for procedures or surgical operations which require sedation or general anesthesia. Inappropriate and prolonged fasting should be avoided, as they create barriers to adequate nutritional therapy and impose added risk with regard to patient outcomes.
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http://dx.doi.org/10.1007/s11894-022-00841-w | DOI Listing |
Pharmaceutics
November 2024
Department of Pharmacy Practice, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 160 Frelinghuysen Road, Piscataway, NJ 08854, USA.
Gabapentin has variable pharmacokinetics (PK), which contributes to difficulty in dosing and increased risk of adverse events. The objective of this study was to leverage gabapentin concentrations from therapeutic drug monitoring (TDM) to develop a population PK (popPK) model and characterize significant covariates that impact gabapentin PK. Data were retrospectively collected from 82 hospitalized adult patients with TDM gabapentin concentrations.
View Article and Find Full Text PDFAnaesthesia
January 2025
Department of Anaesthesia and Intensive Care, Hospices Civils de Lyon, Femme Mère Enfant Hospital, Bron, France.
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View Article and Find Full Text PDFFront Endocrinol (Lausanne)
January 2025
Department of Psychology, University of Miami, Coral Gables, FL, United States.
The neuropeptide oxytocin (OXT) and its receptor (OXTR) have been shown to play an important role in glucose metabolism, and pancreatic islets express this ligand and receptor. In the current study, OXTR expression was identified in α-, β-, and δ-cells of the pancreatic islet by RNA hybridization, and OXT protein expression was observed only in β-cells. In order to examine the contribution of islet OXT/OXTR in glycemic control and islet β-cell heath, we developed a β-cell specific OXTR knock-out (β-KO) mouse.
View Article and Find Full Text PDFSci Rep
January 2025
Department of Cardiovascular Medicine, Jiangsu Provincial People's Hospital Group Taihu Sanatorium of Jiangsu Province, Wuxi, 214086, China.
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View Article and Find Full Text PDFIntroduction: An annual fasting lipid panel (FLP) is recommended for patients with diabetes, with more frequent testing advised during the escalation of cholesterol-lowering therapy. However, the calculated low-density lipoprotein cholesterol (LDL-C) using the Friedewald equation becomes unreliable when triglycerides are ≥400 mg/dL. In such cases, providers must order a separate direct LDL-C assay to obtain accurate results.
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