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View Article and Find Full Text PDFPrediction of radiotherapy toxicity: 20 years of COPERNIC radiosensitivity diagnosis procedure.
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UMR1296 « Radiations : défense, santé, environnement », Institut national de la santé et de la recherche médicale (Inserm), rue Laennec, 69008 Lyon, France; Department of Radiation Oncology, American University of Beirut Medical Center, Riad El-Solh, Beirut 1107-2020, Lebanon; Department of Anatomy, Cell Biology and Physiological Sciences, Faculty of Medicine, American University of Beirut, Bliss Street, 11-0236 Riad El-Solh, Beirut 1107-2020, Lebanon.
Purpose: Since 2004, in the frame of the care pathway, our Research Unit has replied to the demand of expertise of radiation oncologists about the individual radiosensitivity of some of their patients. This procedure, called COPERNIC, is based on a skin biopsy and the radiation-induced nucleoshuttling of the ATM protein (the RIANS model), a major actor of DNA break repair and signaling. In 2016, with the first 117COPERNIC fibroblast lines, we obtained a significant correlation between the maximum number of the nuclear ATM foci, pATM, and the CTCAE severity grade of the post-radiotherapy tissue reactions.
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