AI Article Synopsis
- Limited information exists on SARS-CoV-2 infections in premature infants, but earlier studies indicated a lower risk and milder illness compared to adults.
- The delta variant has been associated with more severe disease in infants, with cases showing serious complications like hyperglycemia and bone marrow dysfunction.
- Three premature infants were reported with confirmed infections from different transmission methods, and all recovered with supportive care, highlighting the need for evaluating COVID-19 in at-risk premature infants.
Article Abstract
Information regarding severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections in premature infants remains limited. Early in the pandemic, several studies reported that the risk of infection in infants was relatively small and that affected infants had a milder disease than what was seen in adults. Since the increase of the delta variant (SARS-CoV-2 B.1.617.2) within the population, there have been increased reports of more severe disease in infants. We present 3 cases of premature, very low birth weight infants with confirmed SARS-CoV-2 infection who presented with significant hyperglycemia and bone marrow dysfunction. Two infants had presumed vertical transmission, and 1 infant was infected by respiratory transmission. Despite the mode of transmission, symptom onset and duration were similar in all infants. All resolved with symptomatic management. In the context of the continuing pandemic, evaluation for SARS-CoV-2 infection should be considered in premature very low birth weight infants who demonstrate certain patterns of acute metabolic and hematologic abnormalities.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10158391 | PMC |
| http://dx.doi.org/10.1542/peds.2021-055331 | DOI Listing |
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