The protective effect of the calcium antagonist diltiazem on methacholine-induced bronchoconstriction was investigated in 19 extrinsic asthmatics. A double-blind cross-over design was used (diltiazem vs. placebo, administered orally for 1 week). We found no significant difference between the two treatment regimens when expressed as the provocation dose of methacholine causing a 20% drop in forced expired volume in 1 s (PD20 FEV1). Some individual patients might nevertheless gain some benefit from diltiazem as an additional treatment in difficult-to-manage asthma.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1159/000194905 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Beta-adrenergic receptor stimulation, histamine receptor inhibition, and potassium channel opening contribute to the relaxant effects of crocetin on airway smooth muscle.
Iran J Basic Med Sci
January 2024
Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Objectives: In the present study, the relaxant effect of crocetin on tracheal smooth muscle cells (TSM) and its possible mechanisms were evaluated.
Materials And Methods: The study was conducted on 54 male Wistar rats in 8 groups. TSM was contracted by methacholine (10 μM) and KCl (60 mM), and the relaxant effects of four cumulative concentrations of crocetin, petal extract of saffron, and theophylline were examined on non-incubated and TSM incubated with propranolol, chlorpheniramine, diltiazem, atropine, glibenclamide, and indomethacin were investigated.
The Relaxant Effect of Crocin on Rat Tracheal Smooth Muscle and Its Possible Mechanisms.
Iran J Pharm Res
January 2019
Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Crocin, a component of saffron, showed hypotensive activity which is perhaps due to vascular smooth muscle relaxant effect. The relaxant effects of saffron on tracheal smooth muscle also could be due to its constituent, crocin. In the present study, the relaxant effects of crocin and its possible mechanisms on rat tracheal smooth muscle were investigated.
View Article and Find Full Text PDFMuscarinic receptors, nitric oxide formation and cyclooxygenase pathway involved in tracheal smooth muscle relaxant effect of hydro-ethanolic extract of Lavandula angustifolia flowers.
Biomed Pharmacother
June 2018
Department of Physiology, School of Medicine, Arak University of Medical Sciences, Arak, Iran. Electronic address:
Background: Lavandula angustifolia (L. angustifolia) Mill. (Common name Lavender) is used in traditional and folk medicines for the treatment of various diseases including respiratory disorders worldwide.
View Article and Find Full Text PDFRelaxant effect of Curcuma longa on rat tracheal smooth muscle and its possible mechanisms.
Pharm Biol
December 2017
a Neurogenic Inflammation Research Centre , Mashhad University of Medical Sciences, Mashhad , Iran.
Context: Turmeric is a spice obtained from the root of Curcuma longa L. (Zingiberaceae) with anti-aging, anticancer, anti-Alzheimer's disease, antioxidant and other medicinal properties.
Objective: The relaxant effect of C.
Possible mechanism(s) for relaxant effects of Foeniculum vulgare on guinea pig tracheal chains.
Pharmazie
July 2004
Department of Physiology, Ghaem Medical Centre, Mashhad University of Medical Sciences, Mashhad, Iran.
In a previous study the relaxant (bronchodilatory) effect of Foeniculum vulgare on isolated guinea pig tracheal chains was demonstrated. To study mechanisms responsible for this effect the present study evaluated the inhibitory effect of this plant on contracted tracheal chains of guinea pig. The relaxant effects of aqueous and ethanol extracts and an essential oil from Foeniculum vulgare were compared to negative controls (saline for aqueous extract and essential oil and ethanol for ethanol extract) and a positive control (diltiazem) using isolated tracheal chains of the guinea pig precontracted by 10 microM methacholine (group 1) and 60 mM KCl (group 2, n = 7 for each group).
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!