Epigenetic regulation and targeting of ECM for cancer therapy.

Am J Physiol Cell Physiol

Department of Biochemistry and Molecular Genetics, The University of Alabama at Birmingham, Birmingham, Alabama.

Published: April 2022

The tumor microenvironment (TME) composed of different types of cells embedded in extracellular matrix (ECM) has crucial effects on cancer growth and metastasis. ECM is made of a variety of proteins that provide structural support to the cells and regulate biological functions by modulating the cross talk among cells, thus effecting tumor growth and progression. In this mini-review, the author discusses epigenetic modifications that regulate the expression of fibrous ECM proteins and glycoproteins and the prospects of targeting them for cancer therapy.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8993518PMC
http://dx.doi.org/10.1152/ajpcell.00022.2022DOI Listing

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