AI Article Synopsis
- The article discusses the successful complete synthesis of Isoginkgetin, a natural compound, along with four new water-soluble versions of it that are phosphate analogues.
- The research also delves into the pharmacological characteristics of these phosphate analogues, examining factors like their stability in the body and how they behave pharmacokinetically.
- Additionally, the study explores the biological effects and activities of these synthesized compounds.
Article Abstract
The first total synthesis of the natural product Isoginkgetin as well as four water-soluble Isoginkgetin-phosphate analogues is reported herein. Moreover, the full study of the phosphate analogue with respect to pharmacological properties (metabolic and plasmatic stabilities, pharmacokinetic, off-target, etc.) as well as and biological activities are disclosed herein.
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| http://dx.doi.org/10.1021/acs.jmedchem.1c01654 | DOI Listing |
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Biological Investigation of a Water-Soluble Isoginkgetin-Phosphate Analogue, Targeting the Spliceosome with Antitumor Activity.
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Article Synopsis
- The article discusses the successful complete synthesis of Isoginkgetin, a natural compound, along with four new water-soluble versions of it that are phosphate analogues.
- The research also delves into the pharmacological characteristics of these phosphate analogues, examining factors like their stability in the body and how they behave pharmacokinetically.
- Additionally, the study explores the biological effects and activities of these synthesized compounds.
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