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The Proportion of FceRI+ Blood Monocytes Increases With the Degree of IgE-Mediated Sensitization in Asthma.
J Investig Allergol Clin Immunol
December 2022
Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden.
Clinical and Translational Significance of Basophils in Patients with Cancer.
Cells
January 2022
St. John's Institute of Dermatology, School of Basic & Medical Biosciences, King's College London, London SE1 9RT, UK.
Article Synopsis
- * They can also be involved in chronic inflammation, infections, and potentially have roles in cancer, although they haven't been thoroughly studied in this context.
- * Researchers are analyzing basophil gene expression in cancer patients to see how they relate to clinical outcomes and exploring their potential to predict reactions to cancer treatments and monitor patient responses.
Uncontrolled asthmatics have increased FceRI and TGF-β-positive MC mast cells and collagen VI in the alveolar parenchyma.
Clin Exp Allergy
March 2018
Department Experimental Medical Science, Lund University, Lund, Sweden.
Background: Asthma has been associated with increased collagen deposition in both conducting airways and alveolar parenchyma. Mast cells (MCs) are key effector cells in asthma and have the ability to affect collagen synthesis. However, the link between clinical control and changes in bronchial and alveolar MC phenotypes and specific collagens in controlled and uncontrolled asthma remains unknown.
View Article and Find Full Text PDFCharacterization of syk expression in human lung mast cells: relationship with function.
Clin Exp Allergy
March 2011
Academic Unit of Respiratory Medicine, The Medical School (Floor M), University of Sheffield, Sheffield, UK.
Background: Previous studies indicate that the protein tyrosine kinase, syk, is critical in transducing FcɛRI-mediated signals. In human basophils, 'releasability' has been linked to the extent of syk expression. Human lung mast cells, like basophils, are also found to be variably responsive to IgE-dependent activation.
View Article and Find Full Text PDFMultiple drug hypersensivity: insight into the underlying mechanism and correlation with autoimmune diseases.
Eur Ann Allergy Clin Immunol
April 2009
Allergy and Immunology Department, IRCCS San Raffaele Hospital, Milan, Italy.
Background: Subjects with drug hypersensitivity are sometimes simultaneously reactive to several drugs. This nosological entity is defined as multiple drug hypersensivity (MDH). Urticaria and angioedema are the commonest clinical manifestations of hypersensitivity drug reactions (HDR).
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