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| http://dx.doi.org/10.1002/cac2.12279 | DOI Listing |
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Matrisomics: Beyond the extracellular matrix for unveiling tumor microenvironment.
Biochim Biophys Acta Rev Cancer
November 2024
Department of Biochemistry & Molecular Biology, Ajou University School of Medicine, Suwon 16499, Republic of Korea; Department of Biomedical Sciences, Graduate School of Ajou University, Suwon 16499, Republic of Korea. Electronic address:
Article Synopsis
- The matrisome is a group of proteins that play a big role in how cancer grows and spreads.
- Scientists are studying these proteins in cancer tissues using new technologies and methods to learn how they work.
- Some matrisome genes behave similarly in different types of cancer, while others change depending on the type, making them important for understanding and treating cancer.
Article Synopsis
- - The study investigated cerebral small-vessel disease (cSVD), a genetic cause of stroke, by analyzing a cohort of suspected familial cases using whole-genome sequencing to identify known and novel genetic variants associated with the disease.
- - Among 257 suspected cSVD cases, 8.9% had variants in known cSVD genes, and 23.6% of those without known causes carried potentially harmful variants; however, none were statistically linked to the disease.
- - The research suggests that rare variants in noncoding and matrisomal genes may contribute to cSVD, impacting tissue development and brain endothelial cell function, but more research is needed to verify these findings.
Epigenetic Mechanisms Histone Deacetylase-Dependent Regulate the Glioblastoma Angiogenic Matrisome and Disrupt Endothelial Cell Behavior In Vitro.
Mol Cell Proteomics
March 2024
Instituto de Ciências Biomédicas e Programa de Pós-graduação em Medicina (Anatomia Patológica), UFRJ/RJ, Rio de Janeiro, Rio de Janeiro, Brazil. Electronic address:
Glioblastoma (GBM) is the most aggressive brain tumor and different efforts have been employed in the search for new drugs and therapeutic protocols for GBM. Epitranscriptomics has shed light on new druggable Epigenetic therapies specifically designed to modulate GBM biology and behavior such as Histone Deacetylase inhibitors (iHDAC). Although the effects of iHDAC on GBM have been largely explored, there is a lack of information on the underlaying mechanisms HDAC-dependent that modulate the repertoire of GBM secreted molecules focusing on the set of Extracellular Matrix (ECM) associated proteins, the Matrisome, that may impact the surrounding tumor microenvironment.
View Article and Find Full Text PDFMatrisomal components involved in regenerative wound healing in axolotl and : implications for biomaterial development.
Biomater Sci
September 2023
Department of Medical BioSciences, Radboud Research Institute, Radboud university medical center, PO Box 9101, 6500 HB Nijmegen, The Netherlands.
Achieving regeneration in humans has been a long-standing goal of many researchers. Whereas amphibians like the axolotl () are capable of regenerating whole organs and even limbs, most mammals heal their wounds fibrotic scarring. Recently, the African spiny mouse ( sp.
View Article and Find Full Text PDFCancer-Associated Fibroblast-Like Tumor Cells Remodel the Ewing Sarcoma Tumor Microenvironment.
Clin Cancer Res
December 2023
Ben Towne Center for Childhood Cancer Research, Seattle Children's Research Institute, Seattle, Washington.
Purpose: Despite limited genetic and histologic heterogeneity, Ewing sarcoma (EwS) tumor cells are transcriptionally heterogeneous and display varying degrees of mesenchymal lineage specification in vitro. In this study, we investigated if and how transcriptional heterogeneity of EwS cells contributes to heterogeneity of tumor phenotypes in vivo.
Experimental Design: Single-cell proteogenomic-sequencing of EwS cell lines was performed and integrated with patient tumor transcriptomic data.
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