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| http://dx.doi.org/10.1093/plcell/koab082 | DOI Listing |
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Unlabelled: Antibiotic resistance is frequently observed shortly after the clinical introduction of an antibiotic. Whether and how frequently that resistance occurred before the introduction is harder to determine, as isolates could not have been tested for resistance before an antibiotic was discovered. Historical collections, like the British National Collection of Type Cultures (NCTC), stretching back to 1885, provide a window into this history.
View Article and Find Full Text PDFDevelopment of Attention-based Prediction Models for All-cause Mortality, Home Care Need, and Nursing Home Admission in Ageing Adults in Spain Using Longitudinal Electronic Health Record Data.
J Med Syst
January 2025
Unitat de Suport a la Recerca Metropolitana Nord, Institut Universitari d'Investigació en Atenció Primària Jordi Gol (IDIAP Jordi Gol), C/ Mare de Déu de Guadalupe, 2, Mataró, 08303, Barcelona, Spain.
Predicting health-related outcomes can help with proactive healthcare planning and resource management. This is especially important on the older population, an age group growing in the coming decades. Considering longitudinal rather than cross-sectional information from primary care electronic health records (EHRs) can contribute to more informed predictions.
View Article and Find Full Text PDFRepeated Autologous Fat Grafting Significantly Increases Mastectomy Flap Thickness in Pre-Pectoral Multi-Stage Composite Expander-to-Implant Breast Reconstruction: Exploring the Concept of a Reverse Expansion.
J Clin Med
January 2025
Department of Plastic, Reconstructive and Aesthetic Surgery and Hand Surgery, Centre Hospitalier Universitaire Vaudois (CHUV), 1011 Lausanne, Switzerland.
: Combining autologous fat grafting with implant placement is meant to improve the quality of implant-based breast reconstruction. The present study explores the concept of multi-stage composite breast reconstruction with repeated sessions of autologous fat grafting to increase mastectomy flap thickness and provide better pre-pectoral implant coverage. : Twenty-five consecutive patients underwent bilateral multi-stage composite expander-to-implant breast reconstruction and reverse expansion from August 2020 to April 2024.
View Article and Find Full Text PDFExperimental evidence that exerting effort increases meaning.
Cognition
January 2025
Department of Psychology, University of Toronto,; Rotman School of Management, University of Toronto.
Efficiency demands that we work smarter and not harder, but is this better for our wellbeing? Here, we ask if exerting effort on a task can increase feelings of meaning and purpose. In six studies (N = 2883), we manipulated how much effort participants exerted on a task and then assessed how meaningful they found those tasks. In Studies 1 and 2, we presented hypothetical scenarios whereby participants imagined themselves (or others) exerting more or less effort on a writing task, and then asked participants how much meaning they believed they (or others) would derive.
View Article and Find Full Text PDFA systematic review of psychometric properties of questionnaires assessing activities of daily living among older adults with neurocognitive disorders.
Aust Occup Ther J
February 2025
School of Physical and Occupational Therapy, Faculty of Medicine, McGill University, Montreal, Quebec, Canada.
Introduction: Mild cognitive impairment (MCI) and Alzheimer's disease (AD) lead to decline in performance in activities of daily living (ADLs). Multiple questionnaires assess this construct among older adults. The objective of this study was to review existing literature studying psychometric properties of questionnaires assessing performance in ADLs of older adults living with MCI and AD specifically.
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