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| http://dx.doi.org/10.15252/embr.202254893 | DOI Listing |
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Enhancing starch hydrolysis in sweet potato ( (L.) Lam.) through CaCl solution mashing: insights into endogenous amylase activity.
J Food Sci Technol
January 2025
Graduate Program in Food Science and Technology, State University of Ponta Grossa, Avenida Carlos Cavalcanti 4748, Ponta Grossa, Paraná 84030-900 Brazil.
Sweet potato ( (L.) Lam.) is a tuber root crop with high economical potential and China is responsible for harvesting roughly 70% of the world production.
View Article and Find Full Text PDFDevelopment of chimeric antigen receptor T cells targeting cancer-expressing podocalyxin.
Regen Ther
March 2025
Department of Cancer Immunotherapy and Immunology, Institute of Medicine, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan.
Chimeric Antigen Receptor (CAR)-T cell therapy has revolutionized the treatment of CD19-positive B-cell malignancies. However, the field is rapidly evolving to target other antigens, such as podocalyxin (PODXL), a transmembrane protein implicated in tumor progression and poor prognosis in various cancers. This study explores the potential of PODXL-targeted CAR-T cells, utilizing a cancer-specific monoclonal antibody (CasMab) technique to enhance the specificity and safety of CAR-T cell therapy.
View Article and Find Full Text PDFMolecular and cellular regulators of embryo implantation and their application in improving the implantation potential of IVF-derived blastocysts.
Reprod Med Biol
January 2025
Laboratory of Animal Breeding and Reproduction, Division of Animal Science, School of Agriculture Utsunomiya University Utsunomiya Tochigi Japan.
Background: In vitro fertilization (IVF) and embryo transfer (ET) are widely used in reproductive biology. Despite the transfer of high-quality blastocysts, the implantation rate of IVF-derived blastocysts remains low after ET.
Methods: This article provides a comprehensive review of current research on embryo implantation regulators and their application to improve the implantation potential of IVF-derived blastocysts.
Local Structure Distortion in Mn, Zn Doped Cu₂V₂O₇: Supercapacitor Performance and Emergent Spin-Phonon Coupling.
Adv Mater
January 2025
Department of Physics, University of Calcutta, 92 A.P.C. Road, Kolkata, 700009, India.
Supercapacitors are rapidly gaining attention as next-generation energy storage devices due to their superior power and energy densities. This study pioneers the investigation of Mn/Zn co-doping in α-Cu₂V₂O₇ (CVO) to enhance its performance as a supercapacitor electrode material. Structural and local Structural properties of Mn/Zn co-doped CVO have been investigated through X-ray Diffraction (XRD), Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM), X-ray Photoelectron Spectroscopy (XPS), and X-ray Absorption Spectroscopy (XAS), revealing significant distortions that enhance supercapacitor performance.
View Article and Find Full Text PDFMicrofluidic-Enabled Self-Directed Hydrogel Microspheres for Multiplexed MicroRNA Assays.
Anal Chem
January 2025
MOE Key Laboratory of Geriatric Nutrition and Health, Department of Bioengineering, Beijing Technology and Business University, Beijing 100048, China.
Multiplexed microRNA (miRNA) detection has proven valuable in disease diagnosis; yet, the development of advanced tools for their analysis remains a subject of broad interest. Here, we propose a novel single-particle method for multiplexed miRNA detection using self-directed hydrogel microspheres, which feature supersegmented compartments for loading analyte probes and an air-encapsulated region that grants the microsphere a unique preferred posture in aqueous solutions. By exploiting microfluidic technology, we can widely adjust the size of the microspheres and the number of compartments can be widely adjusted.
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