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Fluorescent probes for biomolecule detection under environmental stress. | LitMetric

Fluorescent probes for biomolecule detection under environmental stress.

J Hazard Mater

CAS Key Laboratory of Coastal Environmental Processes and Ecological Remediation, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China; School of Pharmacy, Binzhou Medical University, Yantai 264003, China; Center for Ocean Mega-Science, Chinese Academy of Sciences, Qingdao 266071, China. Electronic address:

Published: June 2022

AI Article Synopsis

  • Fluorescent probes have evolved over decades for the visible detection of biomolecules, which are crucial for biological processes and are affected by environmental conditions.
  • Recent advancements highlight how these probes can track the localization and quantities of biomolecules during environmental stress, including various pathological situations.
  • The paper reviews the design and application of small molecule-based fluorescent probes for imaging biomolecules under stressors like hypoxia and chemical exposure, emphasizing their potential in biochemical and biomedical research.

Article Abstract

The use of fluorescent probes in visible detection has been developed over the last several decades. Biomolecules are essential in the biological processes of organisms, and their distribution and concentration are largely influenced by environmental factors. Significant advances have occurred in the applications of fluorescent probes for the detection of the dynamic localization and quantity of biomolecules during various environmental stress-induced physiological and pathological processes. Herein, we summarize representative examples of small molecule-based fluorescent probes that provide bimolecular information when the organism is under environmental stress. The discussion includes strategies for the design of smart small-molecule fluorescent probes, in addition to their applications in biomolecule imaging under environmental stresses, such as hypoxia, ischemia-reperfusion, hyperthermia/hypothermia, organic/inorganic chemical exposure, oxidative/reductive stress, high glucose stimulation, and drug treatment-induced toxicity. We believe that comprehensive insight into the beneficial applications of fluorescent probes in biomolecule detection under environmental stress should enable the further development and effective application of fluorescent probes in the biochemical and biomedical fields.

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Source
http://dx.doi.org/10.1016/j.jhazmat.2022.128527DOI Listing

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