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Risk factors and severity of functional impairment in long COVID: a single-center experience in Croatia. | LitMetric

AI Article Synopsis

  • The study aimed to evaluate the frequency of common symptoms in long COVID and their impact on quality of life, while also identifying factors linked to more severe long COVID outcomes.
  • It involved 261 patients who were either referred to a long COVID outpatient clinic or receiving rehabilitation, with data on their symptoms and functional status collected from December 2020 to May 2021.
  • The results indicated that nearly 80% of patients experienced impaired functional status post-acute COVID-19, with women and those requiring oxygen therapy during the acute phase being more affected, while pre-existing lung disease did not significantly increase risk for long COVID severity.

Article Abstract

Aim: To determine the frequency of common symptoms in long COVID and their effect on the quality of life, and to determine the factors contributing to a more severe long COVID.

Methods: The study enrolled 266 patients who were either referred to long-COVID outpatient clinic or were inpatients undergoing rehabilitation. The data were collected between December 2020 and May 2021. We evaluated the symptoms experienced during acute and long COVID and comorbidities. Functional status was assessed with Post Covid Functional Status (PCFS).

Results: The final sample consisted of 261 patients. After acute COVID-19 period (>4 weeks), almost 80% of patients had impaired functional status. Only 21.5% reported no functional impairment (0 on PCFS scale). A higher PCFS score was associated with female sex (P<0.001) and oxygen therapy requirement during acute disease (P=0.001). However, it was not associated with having a pre-existing lung disease (P=0.749). Disease severity did not pose a risk for developing a more severe long COVID.

Conclusion: Women were at greater risk for developing greater functional impairment in long COVID, although we have no explanation why. Malignant disease and hypertension also presented a risk factor for greater functional impairment. More studies are warranted to determine if patients with certain lung disease are more susceptible to long COVID.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8895334PMC
http://dx.doi.org/10.3325/cmj.2022.27DOI Listing

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