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The mammary hair of Monodelphis domestica and homology of the mammary pilosebacous unit.
J Morphol
September 2024
Department of Ecology & Evolutionary Biology, Yale University, New Haven, Connecticut, USA.
The unitary mammary gland is a synapomorphy of therian mammals and is thought to have evolved from the pilosebaceous organ in the mammalian stem lineage from which the lactogenic patch of monotremes is also derived. One of the key lines of evidence for the homology of the nipple and the lactogenic patch is that marsupials have retained a transient hair associated with developing mammary glands. However, these structures have not been documented since the early 20th-century drawings of Ernst Bresslau.
View Article and Find Full Text PDFSurface Orthogonal Patterning and Bidirectional Self-Assembly of Nanoparticles Tethered by V-Shaped Diblock Copolymers.
Langmuir
August 2024
School of Physics and Information Engineering, Shanxi Normal University, Taiyuan 030031, People's Republic of China.
We investigated the surface orthogonal patterning and bidirectional self-assembly of binary hairy nanoparticles (NPs) constructed by uniformly tethering a single NP with multiple V-shaped AB diblock copolymers using Brownian dynamics simulations in a poor solvent. At low concentration, the chain collapse and microphase separation of binary polymer brushes can lead to the patterning of the NP surface into A- and B-type orthogonal patches with various numbers of domains (valency), = 1-6, that adopt spherical, linear, triangular, tetrahedral, square pyramidal, and pentagonal pyramidal configurations. There is a linear relationship between the valency and the average ratio of NP diameter to the polymers' unperturbed root-mean-square end-to-end distance for the corresponding valency.
View Article and Find Full Text PDFMaculopapular rash with multiple drug hypersensitivity to cotrimoxazole, amikacin, piperacillin/tazobactam, and meropenem in a patient with hairy cell leukemia.
Allergol Select
July 2024
Department of Respiratory Medicine & Allergy, Homerton Healthcare NHS Foundation Trust.
We describe a rare case of a 54-year-old female with hairy cell leukemia, who following treatment for neutropenic sepsis, developed an extensive severe maculopapular exanthema with perifollicular hemorrhage. Cladribine, cotrimoxazole, allopurinol, domperidone, amikacin, piperacillin/tazobactam, and meropenem had all been given in the 9 days prior to eruption onset. Three months later, drug patch testing/delayed intradermal testing was positive to cotrimoxazole, trimethoprim, amikacin, piperacillin/tazobactam, and meropenem, with additional evidence of penicillin cross-reactivity.
View Article and Find Full Text PDFFollicular Becker's Nevus: A Case Report of an Uncommon Clinical Variant.
Cureus
April 2024
Department of Pathology, Saveetha Medical College, Chennai, IND.
Pigmented hairy epidermal nevus, also known as Becker's nevus, has a typical description as a unilateral, hairy in appearance, light to dark brown patch with an irregular but clearly defined border. However, the exact aetiopathogenesis is still poorly comprehended. We report the case of a 19-year-old female who presented with asymptomatic brownish-pigmented macular lesions on the right breast that had slowly increased in size over the past three years.
View Article and Find Full Text PDFPrevalence of tobacco and areca-nut use among patients attending dental teaching hospital in the central province of Sri Lanka and its association with oral mucosal lesions; a cross sectional study.
J Oral Biol Craniofac Res
December 2023
Centre for Research in Oral Cancer and Department of Oral Medicine and Periodontology, Faculty of Dental Sciences, University of Peradeniya, Sri Lanka.
Article Synopsis
- Tobacco and areca-nut are linked to a high prevalence of oral cancer in Sri Lanka, particularly among males, prompting a study to assess their use and correlation with oral lesions.
- A survey of 368 patients revealed that 23.9% used tobacco and 25.3% used areca-nut, with a notable portion mixing the two substances.
- The study found a significant connection between substance use and various oral lesions, indicating over 90% of users experienced such issues, highlighting the need for awareness programs to mitigate these health risks.
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