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Sepsis-Associated Cardiomyopathy: Long-Term Prognosis, Management, and Guideline-Directed Medical Therapy.
Curr Cardiol Rep
January 2025
Director, Cardiac Intensive Care Emory Heart & Vascular Center, Emory University School of Medicine, Atlanta, GA, USA.
Purpose Of Review: To explore the definitions of sepsis-induced cardiomyopathy and how that impacts interpretation of the available data and considerations of long-term prognosis and management.
Recent Findings: The field of sepsis-induced cardiomyopathy has been hampered by lack of consensus about its proper definition, with a great deal of heterogeneity in clinical trial data in both individual studies and meta-analyses and consequent disparity of estimates of incidence, prognosis, and clinical significance. New diagnostic techniques, while potentially shedding light on pathophysiology, have only exacerbated these challenges.
Stability of Respiratory Syncytial Virus in Nasal Aspirate From Patients Infected With RSV.
Influenza Other Respir Viruses
December 2024
Laboratory for Drug Discovery and Disease Research, Shionogi & Co, Ltd, Osaka, Japan.
Background: Evaluation of infectious virus titer is a challenge for respiratory syncytial virus (RSV) clinical trials because of the labile nature of RSV and rapid loss of infectivity without proper specimen handling. However, there has been no rigorous investigation into RSV stability in clinical specimens.
Methods: RSV stability was investigated by evaluating virus titers and defined as titer variation from baseline within three standard deviations of our titration assay.
Drug molecules beyond chemical biology: fluorescence- and DFT-based investigations for fluoride ion sensing and the trace detection of chloroform.
RSC Adv
November 2024
State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences Changchun 130022 P. R. China.
Article Synopsis
- Excessive fluoride use and chloroform exposure pose health risks, prompting the need for effective sensors to monitor these substances.
- Researchers investigated etoricoxib (ECX) as a safe and available sensor, revealing its strong fluorescence response for detecting fluoride and chloroform at very low levels.
- Advanced analyses, including UV-Vis and DFT studies, confirmed that ECX operates through non-covalent interactions, making it a promising tool for real-time detection of fluoride and moisture in various samples.
Adequacy of Anesthesia Guidance for Combined General/Epidural Anesthesia in Patients Undergoing Open Abdominal Infrarenal Aortic Aneurysm Repair; Preliminary Report on Hemodynamic Stability and Pain Perception.
Pharmaceuticals (Basel)
November 2024
Collegium Medicum, WSB University, 41-300 Dabrowa Gornicza, Poland.
Article Synopsis
- Hemodynamic instability and inappropriate postoperative pain perception (IPPP) pose significant challenges in managing patients undergoing elective open lumbar aortic aneurysm repair under general anesthesia, with inadequate opioid use risking adverse events.
- In a study involving 75 patients, three types of postoperative analgesia were tested: thoracic epidural anesthesia with ropivacaine, thoracic epidural with bupivacaine, and intravenous metamizole/tramadol, with the impact on pain levels and hemodynamic stability measured.
- Results showed that nearly half of the patients still experienced IPPP despite preventive measures, and while no acute pain was reported in the ropivacaine group, this was associated with noticeable hemodynamic instability; however
Nanowire-like phosphorus modulated carbon-based iron nanozyme with oxidase-like activity for sensitive detection of choline and dye degradation.
Talanta
February 2025
Department of Analytical Chemistry, College of Chemistry, Jilin University, Changchun, 130012, PR China. Electronic address:
Choline is mainly supplemented through food intake, lack of choline would result in diseases like liver cirrhosis, hardening of the arteries, or neurodegenerative disorders. The accurate detection of choline is important for human health. Herein, a novel nanowire-like phosphorus/nitrogen co-doped carbon-based iron nanozyme (Fe-NPC) with outstanding oxidase-like activity was synthesized, and the influence of phosphorus doping on oxidase-like activity was explored.
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