Engineering surface patterns on nanoparticles: new insights into nano-bio interactions.

J Mater Chem B

Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medica, Hubei Engineering Research Center for Biomaterials and Medical Protective Materials, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan 430074, China.

Published: April 2022

AI Article Synopsis

  • * This review highlights the impact of chemical surface patterns on how nanoparticles interact with cell membranes, recognize viruses, and adsorb proteins.
  • * By designing nanoparticles with specific surface microstructures, researchers aim to enhance their effectiveness in biomedical applications, such as in the development of nano-drug carriers.

Article Abstract

The surface properties of nanoparticles affect their fate in biological systems. Based on nanotechnology and its methodology, pioneering studies have explored the effects of chemical surface patterns on the behavior of nanoparticles and provided many new insights into nano-bio interfaces. In this review, we would like to provide a summary of how the nanoparticle surface pattern modulates its biological effects. The relationship between the surface pattern of nanoparticles and the generated interaction with cell membranes, recognition of viruses and adsorption of proteins was discussed. On this basis, we believe that a reasonable design of the surface microstructure will promote the application of artificial nanoparticles in biomedicine and provide a new strategy for improving the design of nano-drug carriers.

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Source
http://dx.doi.org/10.1039/d1tb02549jDOI Listing

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