AI Article Synopsis
- Boron nanoparticles (BNPs) with hydroxyl group functionalization were synthesized through a series of chemical processes including bromination and hydrolyzation.
- The characterization of these functionalized BNPs involved multiple techniques such as NMR spectroscopy, FT-IR, ICP-OES, TEM, DLS, and XPS to confirm their properties.
- The nanoparticles demonstrated significant antimalarial activity against the 3D7 strain, with an IC value of 0.0021 μM, while exhibiting low toxicity across various cancer and cell lines.
Article Abstract
Boron nanoparticles (BNPs), functionalized with hydroxyl groups, were synthesized by a cascade process, followed by bromination and hydrolyzation reactions. These functionalized BNPs, (B (OH) ), were characterized using H and B NMR spectra, Fourier-transform infrared (FT-IR) spectroscopy, inductively coupled plasma-optical emission spectroscopy (ICP-OES), transmission electron microscopy (TEM), dynamic light scattering (DLS), and X-ray photoelectron spectroscopy (XPS) methods. These nanoparticles were also evaluated for their antimalarial activity against (3D7 strain) with an IC value of 0.0021 μM and showed low toxicity to Uppsala 87 malignant glioma (U87MG) cell lines, malignant melanoma A375 cell lines, KB human oral cancer cell lines, rat cortical neuron cell lines, and rat fibroblast-like synoviocyte (FLS) cell lines.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8867546 | PMC |
| http://dx.doi.org/10.1021/acsomega.1c05888 | DOI Listing |
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