AI Article Synopsis
- Arterial stiffness, along with systolic and diastolic blood pressure, is proposed as a predictive factor for developing hypertension in normotensive adults, indicating its role beyond just a consequence of hypertension.
- A systematic review and meta-analysis were conducted using various medical databases to analyze the relationship between arterial stiffness, blood pressure measurements, and the incidence of hypertension.
- The results showed significant associations between higher arterial stiffness and both systolic and diastolic blood pressure with hypertension, highlighting the need for preventive strategies that include monitoring arterial stiffness to mitigate cardiovascular risks.
Article Abstract
Background: Arterial stiffness is an independent predictor of cardiovascular and all-cause mortality that is classically regarded as a consequence of arterial hypertension. However, a growing number of studies have shown that arterial stiffness is involved in the pathogenesis and prognosis of arterial hypertension. Thus, in this systematic review and meta-analysis, we aimed to assess whether arterial stiffness, as measured by pulse wave velocity, systolic blood pressure and diastolic blood pressure are associated with incident hypertension.
Methods: The Scopus, PubMed, Web of Science and Cochrane Library databases were searched from inception to March 30, 2021. The DerSimonian and Laird method was used to compute pooled relative risk estimates and their respective 95% confidence intervals of association between incident hypertension with pulse wave velocity, systolic blood pressure and diastolic blood pressure.
Results: Our findings provide a synthesis of the evidence supporting that the higher arterial stiffness (RR: 1.09; 95% CIs: 1.05, 1.12), systolic blood pressure (RR: 1.08; 95% CIs: 1.05, 1.10) and diastolic blood pressure (RR: 1.08; 95% CIs: 1.04, 1.12) are associated with incident hypertension in normotensive adult subjects, with similar independent predictive values. However, our results should be interpreted with caution because the meta-analyses performed showed considerable heterogeneity.
Conclusions: Our results showed that higher pulse wave velocity, systolic blood pressure and diastolic blood pressure are associated with incident hypertension. These findings are of clinical importance, supporting arterial stiffness as an additional tool for the prevention of arterial hypertension and being a fundamental component to reduce cardiovascular morbidity and mortality.
Systematic Review Registration: This study was registered in PROSPERO https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=236435 (Registration number: CRD42021236435).
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8873377 | PMC |
| http://dx.doi.org/10.3389/fcvm.2022.798934 | DOI Listing |
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