AI Article Synopsis
- Detection of SARS-CoV-2 antibodies in serum is being used to identify COVID-19 cases and track immune response over time.
- A study analyzed 148 serum samples from 37 COVID-19 patients and found that neutralizing antibodies and IgG can persist at low levels for 190-266 days post-infection.
- These findings enhance understanding of antibody duration in COVID-19 patients and can inform evaluations of immune responses following vaccination.
Article Abstract
Detection of serum-specific SARS-CoV-2 antibody has become a complementary means for the identification of coronavirus disease 2019 (COVID-19). As we already know, the neutralizing antibody titers in patients with COVID-19 decrease during the course of time after convalescence, whereas the duration of antibody responses in the convalescent patients has not been defined clearly. In the current study, we collected 148 serum samples from 37 confirmed COVID-19 cases with different disease severities. The neutralizing antibodies (Nabs), IgM and IgG against COVID-19 were determined by CLIA Microparticle and microneutralization assay, respectively. The time duration of serum titers of SARS-CoV-2 antibodies were recorded. Our results indicate that IgG (94.44%) and Nabs (89.19%) can be detected at low levels within 190-266 days of disease onset. The findings can advance knowledge regarding the antibody detection results for COVID-19 patients and provide a method for evaluating the immune response after vaccination.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8879838 | PMC |
| http://dx.doi.org/10.3389/fmed.2022.829273 | DOI Listing |
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