AI Article Synopsis
- - The study focuses on understanding how factors related to antitumor immunity affect pancreatic cancer (PC), suggesting that the quality of neoantigens may be more important than their quantity for immune responses and patient survival.
- - Researchers analyzed genomic data from paired normal and tumor tissues of 13 PC patients, discovering that those who survived longer had neoantigens with higher similarity-to-self scores, while short-term survivors had neoantigens with lower similarity-to-self scores.
- - The findings indicate that instead of tumor mutational load or the quantity of neoantigens, a low similarity-to-self score is linked to better immune cell infiltration and improved patient survival.
Article Abstract
Introduction: Factors underlying antitumor immunity in pancreatic cancer (PC) are poorly understood. We hypothesized that not neoantigen quantity, but quality, is related to immune cell infiltration and survival.
Methodology: We performed genomic and transcriptomic profiling of paired normal, tumor tissue of 13 patients with PC with distinct survival times. Additionally, neoantigens prediction and immunological profiling were performed.
Results: The proportion of neoantigens with a low similarity-to-self score was higher in short-term survivors ( < 0.0001), while mutational load and burden, similarity-to-known-pathogens, and immunogenicity of neoantigens were not associated with immune cell infiltration or survival.
Discussion: No tumor mutational load or neoantigen quantity, but low similarity-to-self score, was associated with immune cell infiltration and survival.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8864178 | PMC |
| http://dx.doi.org/10.3389/fmed.2021.751110 | DOI Listing |
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