AI Article Synopsis
- Esterification can be efficiently carried out in water using a commercially available lipase and just 2 wt% of the surfactant TPGS-750-M, achieving 100% selectivity for primary alcohols.
- The process operates without any co-factors and maintains a 1:1 ratio between alcohols and carboxylic acids.
- An additive called PhCF enhances the range of acid/alcohol combinations that can be used, allowing for various 1-pot, multi-step reactions to be performed in an aqueous environment.
Article Abstract
Esterification in an aqueous micellar medium is catalyzed by a commercially available lipase in the absence of any co-factors. The presence of only 2 wt% designer surfactant, TPGS-750-M, assists in a 100% selective enzymatic process in which only primary alcohols participate (in a 1 : 1 ratio with carboxylic acid). An unexpected finding is also disclosed where the simple additive, PhCF (1 equiv. substrate), appears to significantly extend the scope of usable acid/alcohol combinations. Taken together, several chemo- and bio-catalyzed 1-pot, multi-step reactions can now be performed in water.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8809412 | PMC |
| http://dx.doi.org/10.1039/d1sc05660c | DOI Listing |
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Article Synopsis
- Esterification can be efficiently carried out in water using a commercially available lipase and just 2 wt% of the surfactant TPGS-750-M, achieving 100% selectivity for primary alcohols.
- The process operates without any co-factors and maintains a 1:1 ratio between alcohols and carboxylic acids.
- An additive called PhCF enhances the range of acid/alcohol combinations that can be used, allowing for various 1-pot, multi-step reactions to be performed in an aqueous environment.
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