AI Article Synopsis
- The study examines the genetic variant rs10937405 and its association with leukemia specifically in the North Indian population of Jammu and Kashmir, which has not been previously explored.
- The research involved 588 individuals (188 with leukemia and 400 controls), and used a TaqMan assay to analyze the genetic variant.
- Results showed a significant association between rs10937405 and leukemia, indicating it may serve as a risk factor, potentially aiding in the development of diagnostic markers for leukemia in this population.
Article Abstract
Background: The role of single nucleotide polymorphism rs10937405 (C>T) of the gene in cancer including leukemia has previously been studied in different world populations; however, the role of this variant in leukemia in the North Indian population of Jammu and Kashmir is still unknown.
Objectives: In the present study, we investigated the association of genetic variant rs10937405 with leukemic in the Jammu and Kashmir population.
Methods: A total of 588 subjects, (188 cases and 400 controls) were recruited for the study. The rs10937405 variant was genotyped by using the real-time based TaqMan assay.
Results: A statistically significant association was observed between the rs10937405 and leukemia [OR of 1.94 (95% CI 1.51-2.48), p=1.2x10-6].
Conclusion: The current study concludes that the rs10937405 variant is a risk factor for the development of leukemia in the population of Jammu and Kashmir, North India. However, it would be interesting to explore the contribution of this variant in other cancers as well. Our findings will help in the development of diagnostic markers for leukemia in the studied population and potentially for other North Indian populations.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8843251 | PMC |
| http://dx.doi.org/10.4314/ahs.v21i3.34 | DOI Listing |
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