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Cardiovascular Effects of High-Frequency Magnetic Seizure Therapy Compared With Electroconvulsive Therapy. | LitMetric

AI Article Synopsis

  • Magnetic seizure therapy (MST) is a new treatment for depression that appears effective like electroconvulsive therapy (ECT) but causes fewer cognitive side effects.
  • A study compared the cardiovascular effects of 100 Hz MST and ECT in 45 patients, measuring heart rate, blood pressure, and other metrics during and after treatment sessions.
  • Results showed ECT led to significantly higher cardiovascular responses than MST, especially during seizures, suggesting MST may be a safer alternative for patients with cardiovascular issues.

Article Abstract

Background: Magnetic seizure therapy (MST) is a novel convulsive therapy that has been shown to have antidepressant efficacy comparable to electroconvulsive therapy (ECT) with fewer cognitive side effects. However, the cardiovascular (CVS) effects of high frequency MST in comparison to ECT have not been investigated.

Materials And Methods: Forty-five patients with depression received 6 treatment sessions of 100 Hz MST versus 6 bifrontal ECT treatments in a nonrandomized comparative clinical design. Data on CVS function including heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP), and rate pressure product (RPP) were collected at baseline (T0), after the induction of anesthesia but before the electrical stimulation (T1), during convulsion (T2), 2 minutes after cessation of motor seizure (T3), 5 minutes after cessation of motor seizure (T4), and 10 minutes after cessation of motor seizure (T5). Comparisons were made with baseline data and between MST and ECT groups.

Results: There were statistically significant elevations in the maximum HR, SBP, DBP, and RPP in patients receiving ECT compared with MST both in the initial and sixth treatments (all P < 0.05). Particularly, at T2, the ECT group had significantly higher HR, SBP, DBP, and RPP than those in MST group both in initial and sixth treatment (all P < 0.001). At the sixth treatment, the ECT group had significantly higher SBP, DBP, and RPP during the treatment than in the MST group (all P < 0.001).

Limitations: The anesthetic choices for this study may limit the generalizability of our findings. The sample size was relatively small.

Conclusions: Compared with ECT, high-frequency MST has fewer CVS side effects and may be a safer option for depression patients with CVS disorders.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9422761PMC
http://dx.doi.org/10.1097/YCT.0000000000000833DOI Listing

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