AI Article Synopsis
- The CHCl/MeOH extract from Tephrosia uniflora stems produced a new compound called (S)-elatadihydrochalcone-2'-methyl ether along with three known compounds: elongatin, (S)-elatadihydrochalcone, and tephrosin.
- Elongatin exhibited moderate antibacterial effects against Bacillus subtilis and showed toxicity against MCF-7 human breast cancer cells.
- The study suggests revising the structures of three β-hydroxydihydrochalcones to flavanones based on comparisons of literature and experimental NMR data.
Article Abstract
The CHCl/MeOH (1:1) extract of the stems of Tephrosia uniflora yielded the new β-hydroxydihydrochalcone (S)-elatadihydrochalcone-2'-methyl ether (1) along with the three known compounds elongatin (2), (S)-elatadihydrochalcone (3), and tephrosin (4). The structures were elucidated by NMR spectroscopic and mass spectrometric data analyses. Elongatin (2) showed moderate antibacterial activity (EC of 25.3 μM and EC of 32.8 μM) against the Gram-positive bacterium Bacilus subtilis, and comparable toxicity against the MCF-7 human breast cancer cell line (EC of 41.3 μM). Based on the comparison of literature and predicted NMR data with that obtained experimentally, we propose the revision of the structures of three β-hydroxydihydrochalcones to flavanones.
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| http://dx.doi.org/10.1016/j.fitote.2022.105166 | DOI Listing |
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