Effect of calorie restriction diet on levels of C reactive protein (CRP) in obesity: A systematic review and meta-analysis of randomized controlled trials.

Diabetes Metab Syndr

Division of Endocrinology and Metabolism, Internal Medicine Department, Faculty of Medicine Universitas Indonesia, Dr. Ciptomangunkusumo National General Hospital, Jakarta, Indonesia. Electronic address:

Published: March 2022

Background And Aims: Chronic inflammation in obese patients can be managed through a calorie-restricted diet, characterized by reduced C - reactive protein (CRP). This study aims to assess the role of such diet on CRP.

Methods: Literature searches were performed using search engines. Randomized controlled trials were included. Calorie-restricted diets in combination with non-diet interventions were excluded.

Results: Calorie restriction decreased CRP in obese patients with a mean difference of -0.22 (95% CI -0.40 to -0.04, p 0.006).

Conclusions: Calorie-restricted diet reduces CRP. Diet administration >12 weeks had a beneficial effect.

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Source
http://dx.doi.org/10.1016/j.dsx.2022.102388DOI Listing

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